ID A0A1S3A636_ERIEU Unreviewed; 377 AA.
AC A0A1S3A636;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
GN Name=ERGIC2 {ECO:0000313|RefSeq:XP_007529985.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007529985.1};
RN [1] {ECO:0000313|RefSeq:XP_007529985.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC Golgi. {ECO:0000256|RuleBase:RU369013}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC protein {ECO:0000256|RuleBase:RU369013}.
CC -!- SIMILARITY: Belongs to the ERGIC family.
CC {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
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DR RefSeq; XP_007529985.1; XM_007529923.2.
DR AlphaFoldDB; A0A1S3A636; -.
DR STRING; 9365.ENSEEUP00000006062; -.
DR GeneID; 103119610; -.
DR CTD; 51290; -.
DR eggNOG; KOG2667; Eukaryota.
DR InParanoid; A0A1S3A636; -.
DR OrthoDB; 506854at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR InterPro; IPR045888; Erv.
DR InterPro; IPR012936; Erv_C.
DR InterPro; IPR039542; Erv_N.
DR PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR PANTHER; PTHR10984:SF30; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2; 1.
DR Pfam; PF07970; COPIIcoated_ERV; 1.
DR Pfam; PF13850; ERGIC_N; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU369013};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU369013}.
FT DOMAIN 13..98
FT /note="Endoplasmic reticulum vesicle transporter N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13850"
FT DOMAIN 167..331
FT /note="Endoplasmic reticulum vesicle transporter C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07970"
SQ SEQUENCE 377 AA; 42497 MW; 71E2A5424EA106D7 CRC64;
MRRLNRKKTL SLVKELDAFP KVPESYVETS ASGGTVSLIA FTTMALLTIM EFSVYQDTWM
KYEYEVDKDF SSKLRINIDI TVAMKCQYIG ADVLDLAETM VASADGLVYE PTLFDLSPQQ
KEWQRMLQLI QSRLQEEHSL QDVIFKSAFK SSSTALPPRE DNPSEPPDAC RIHGHLYVNK
VAGNFHITVG KAIPHPRGHA HLAALVNHES YNFSHRIDHL SFGELVPGII NPLDGTEKIA
VDHNQMFQYF ITVVPTKLHT YKISADTHQF SVTERERVIN HAAGSHGVSG IFIKYDLSSL
MVTVTEEHMP FWQFFVRLCG IVGGIFSTTG MLHGIGKFIV ELICCRFRLG SYKPVSSVPF
EDGHTDNHLP LLENNTH
//
