ID A0A1S3A662_ERIEU Unreviewed; 356 AA.
AC A0A1S3A662;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Heparan sulfate 2-O-sulfotransferase 1 {ECO:0000256|ARBA:ARBA00039773};
GN Name=HS2ST1 {ECO:0000313|RefSeq:XP_007530021.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530021.1};
RN [1] {ECO:0000313|RefSeq:XP_007530021.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 3 family.
CC {ECO:0000256|ARBA:ARBA00010569}.
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DR RefSeq; XP_007530021.1; XM_007529959.2.
DR AlphaFoldDB; A0A1S3A662; -.
DR STRING; 9365.ENSEEUP00000004899; -.
DR GeneID; 103119648; -.
DR CTD; 9653; -.
DR eggNOG; KOG3922; Eukaryota.
DR InParanoid; A0A1S3A662; -.
DR OrthoDB; 5401406at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007734; Heparan_SO4_2-O-STrfase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005331; Sulfotransferase.
DR PANTHER; PTHR12129; HEPARAN SULFATE 2-O-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR12129:SF17; HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1; 1.
DR Pfam; PF03567; Sulfotransfer_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT COILED 24..51
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 356 AA; 41944 MW; 439A7112A5F5DD6C CRC64;
MGLLRIMMPP KLQLLAVVAF AVAMLFLENQ IQKLEESRSR LERAIARHEV REIEQRQTMD
GPRQDATLDE EEDMVIIYNR VPKTASTSFT NIAYDLCAKN RYHVLHINTT KNNPVMSLQD
QVRFVKNITS WKEMKPGFYH GHVSYLDFAK FGVKKKPIYI NVIRDPIERL VSYYYFLRFG
DDYRPGLRRR KQGDKKTFDE CVAEGGSDCA PEKLWLQIPF FCGHSSECWN VGSRWAMDQA
KYNLINEYFL VGVTEELEDF IMLLEAALPR FFRGATELYR TGKKSHLRKT TEKKVPTKQT
IAKLQQSDIW KMENEFYEFA LEQFQFIRAH AVREKDGDLY ILTQNFFYEK IYPKSN
//
