ID A0A1S3A6E0_ERIEU Unreviewed; 370 AA.
AC A0A1S3A6E0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
DE EC=2.8.2.20 {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
GN Name=TPST1 {ECO:0000313|RefSeq:XP_007530119.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530119.1};
RN [1] {ECO:0000313|RefSeq:XP_007530119.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC cosubstrate. {ECO:0000256|ARBA:ARBA00003886,
CC ECO:0000256|RuleBase:RU365018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000411,
CC ECO:0000256|RuleBase:RU365018};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}.
CC -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR RefSeq; XP_007530119.1; XM_007530057.2.
DR AlphaFoldDB; A0A1S3A6E0; -.
DR STRING; 9365.ENSEEUP00000008473; -.
DR GeneID; 103119732; -.
DR CTD; 8460; -.
DR eggNOG; KOG3988; Eukaryota.
DR InParanoid; A0A1S3A6E0; -.
DR OrthoDB; 5391764at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR026634; TPST-like.
DR PANTHER; PTHR12788:SF4; PROTEIN-TYROSINE SULFOTRANSFERASE 1; 1.
DR PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR Pfam; PF13469; Sulfotransfer_3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018}.
SQ SEQUENCE 370 AA; 42139 MW; 3E86256159DA14FD CRC64;
MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PLKLENTKTT VRTNVGNKTN
KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDVRCGEE TRVIPRILAL KQMWSRSSKE
KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG EPAPYLCNKD PFALKSLTYL ARLFPNAKFL
LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCVEVG YKKCMLVHYE
QLVLHPERWM RTLLKFLHIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVAALS
KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KILENTRRVY KGEFQLPDFL
KEKSQTQQAE
//