ID A0A1S3A6H9_ERIEU Unreviewed; 760 AA.
AC A0A1S3A6H9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=LOW QUALITY PROTEIN: calpain-7 {ECO:0000313|RefSeq:XP_007530171.1};
GN Name=CAPN7 {ECO:0000313|RefSeq:XP_007530171.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530171.1};
RN [1] {ECO:0000313|RefSeq:XP_007530171.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR RefSeq; XP_007530171.1; XM_007530109.2.
DR STRING; 9365.ENSEEUP00000004623; -.
DR CTD; 23473; -.
DR eggNOG; KOG0045; Eukaryota.
DR InParanoid; A0A1S3A6H9; -.
DR OrthoDB; 230045at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd02681; MIT_calpain7_1; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 2.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF04212; MIT; 2.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00745; MIT; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF116846; MIT domain; 2.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 262..487
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 162..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 405
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 425
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 760 AA; 86892 MW; 8AD3107B8CA3C1C8 CRC64;
MDASALERDA VQFARLAVQR DQEGRYPEAV FYYKEAAQAL IYAEMAGSGL ERIQDKINEY
LERVQALHSA VQSKSADPLK SKHQLDLERA HFLVTQAFDE DEKGNVDDAI ELYTEAVDLC
LKTSYETADK TLQNKLKQLA RQALDRAEAL SEPLTKPLCK IKSTNIKPKP PPTRTHFPLG
ANPFHEKPQP FVSPQSCDAQ GQKYTAEEIE VLRTTSKING IEYVPFMNID LRERFAYPMP
FCYSKRYAVY ERRFYQXLSN IIYPQNKDGE PEYNPCGKYM VKLHLNGVPR KVIIDDQLPV
DHKGELLCSY SNNKSELWVS LIEKAYMKVM GGYDFPGSNS NIDLHALTGW IPERIAMHSD
SQTFSKDNSF RMLYQRFHKG DVLITASTGM MSEAEGEKWG LVPTHAYAVL DIREFKGLRF
IQLKNPWSHL RWKGRYSEND VKNWTPELQK YLNFDPRTAQ KIDNGIFWIS WDDLCQYYDV
IYLSWNPGLF KESTCIHSTW DAKQGPVKDV YSLANNPQYK LEVQCPQGGA AVWVLLSRHI
TDKDDFANNR EFITMVVYKT DGKKVYYPAD PAPYIDGIRI NSPHYLTKIK LTTPGTHTFT
LVVSQYEKQN TIHYTVRVYS ACSFTFSKIP SPYTLSKQIN GKWSGQSAGG CGNFQETHKN
NPIYQFHIEK PGPLLIELRG PRQYSVGFEI VTVSTAGDPG PHGFQRKSSG DYRCGFCYLE
LENIPVGIYN IIPSTFLPKQ EGPFFLDFNS TVPVKTAQLQ
//
