ID A0A1S3A6M7_ERIEU Unreviewed; 1536 AA.
AC A0A1S3A6M7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Protein dispatched homolog 1 {ECO:0000313|RefSeq:XP_007530240.2};
GN Name=DISP1 {ECO:0000313|RefSeq:XP_007530240.2};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530240.2};
RN [1] {ECO:0000313|RefSeq:XP_007530240.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dispatched family.
CC {ECO:0000256|ARBA:ARBA00038046}.
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DR RefSeq; XP_007530240.2; XM_007530178.2.
DR STRING; 9365.ENSEEUP00000007858; -.
DR CTD; 84976; -.
DR eggNOG; KOG1934; Eukaryota.
DR eggNOG; KOG3664; Eukaryota.
DR InParanoid; A0A1S3A6M7; -.
DR OrthoDB; 2875706at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45951:SF4; PROTEIN DISPATCHED HOMOLOG 1; 1.
DR PANTHER; PTHR45951; PROTEIN DISPATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 186..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1003..1025
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1032..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1072..1089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1101..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 517..651
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 14..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1536 AA; 168421 MW; 16618A699F6E2055 CRC64;
MALSNDLVVL SSGSMAPGAT GPGPLAPGNG DPTAPQLTPK EAPRAKVSPN GCLQVNGTVK
SSFLPLDSQR GAPQLLAPCC HPCPYHQPPT SHHGHQERLP EAGPGAPSAW APCCMQPHPD
YIASLCSKHS PVYQAPCCLQ PAPSFCLHHP WPDHFQHQSV RQHVADIRSS RPFKLPKSYA
ALIADWPVVV LGMCTVLIVV CALVGVLVPE LPDFSDPLLG FEPRGTAIGQ RLVTWNNMVK
NTGYKATLAN YPFKYADEQA KSHRNDHHER KKREVDWNFH KDSFFCDVPS DRYSRVVFTS
AGGETLWNLP AIKSMCNVDN SRIRSHPQFG DLCQRTTAAS CCPSWTLGNY IAILNNRSSC
QKIVERDVSH TLKLLRACAK HYHNGTLEPD CWDAAARRKD QLKCSDVPRK CTKYNAVYQI
LHYLVDKDFL SPRAAEGAAP ALKHSMLFSP TEKGESMMNI YLDNFESWNA SDGVTAVTGI
EFGIKHSLFQ DYLLMDTVYP AIAIAIVLLV MCVYTRSVFI TLMTMFAVIS SLIVSYFLYR
VVFHFEFFPF MNLTALVILV GIGADDAFVL CDVWSHTKGD RPQADTAETV SVTLRHAALS
MFVTSFTTAA AFYANYVSNI TAIRCFGVYA GTAILVNYVL MVTWLPAVVV LHERYLLGTF
GCFLERPQQA FEHKSCWVAA RHRCRRALCA ASEASRVFFE KVLPCLVIRF RYLWLLWFLA
LTLGGAYVVC VNPKMKLPSL ELAEFQVFRA SHPFERYDAE YKKLFMFERV RHGEELHMPI
TVIWGVAPRD TGDPLNPRSK GRLTLDTSFN MASPASQAWI LRFCQKLRNQ TFFHQTDEQD
FTSCFIETFK QWMENQDCDE PAPHPCCRRW SFPYKQEVFE LCIKRAIMEL ERSTGYHLDG
KTPGPRFDAN DTIRAVVLEF QSAHLFTLAY EKMHRFYREV DGWMASELSS APEGLSNGWF
VSSLEFYDLQ DSLSDGTLVA MGLSVAVAFS VMLLTTWSLV ISLYAILSIA GTIFVTVGSL
VLLGWELNVL ESVTISVAVG LSVDFTVHYG VAYRLAPDAD REGKVIFSLS RMGSAIAMAA
LTTFVAGAMM MPSTVLAYTQ LGTFMMLIMC VSWAFATFFF QCVCRCLGPQ GTCGQIPLPR
TLRCGAFSHA PTPGPGDKGP PGKAHALDAY HLAPRGRKAE REQHGLYELE PLAPRGHRAA
EKTAYEEPGG CPEGLGATGR SGRREAGSAL LQPCRDQHTL CQLFSLSHGC SCPAAYRPLK
CGPSSCPQAA DSLCHHCAPT VPSSGAPGQA PEGFVRSTAP LLHPCPCLQG RLRAAGLANS
LSPRGLSIHP GQCAQAPETA ARAGTPCGQG DVEERHPRAG APQETGCGPE CKPRAVSGTL
EGGEGTADRD AASPSQTASG PCWSQTDATL NSEHSPPKEP ELTSGPLLGE AGHRQPWGRG
GRGKCGSLDC QVPGADTGLP TGLAHPELSG GKSCDRDGLR HRDRTLSWEC LEHGGYLPVE
RKCSPAVKTA ERGSELASMV TLKTLPRFPH AQSSFL
//
