ID A0A1S3A6T1_ERIEU Unreviewed; 865 AA.
AC A0A1S3A6T1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Toll-like receptor 5 {ECO:0000313|RefSeq:XP_007530239.1};
GN Name=TLR5 {ECO:0000313|RefSeq:XP_007530239.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530239.1};
RN [1] {ECO:0000313|RefSeq:XP_007530239.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007530239.1; XM_007530177.2.
DR AlphaFoldDB; A0A1S3A6T1; -.
DR STRING; 9365.ENSEEUP00000002873; -.
DR GeneID; 103119850; -.
DR CTD; 7100; -.
DR eggNOG; KOG4641; Eukaryota.
DR InParanoid; A0A1S3A6T1; -.
DR OrthoDB; 4633557at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF525; TOLL-LIKE RECEPTOR 5; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..865
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010359897"
FT TRANSMEM 640..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 691..836
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 843..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 96994 MW; A4271254A8F75572 CRC64;
MTNHLDLLLG VVLVASPLLG LPPCSSDGQI ALYHACNLTR IPQVPSSTER LLLSFNAIGM
VTSDSFPFLG RLWLLEIGAQ ETPLSVDKDA FRNLPNLKVL DLGKTPLGFL HPDAFQGLPR
LSELRLFGCG LSSAVLTGGH FRHLESLARL DLSSNEIQNL SLHPSFRGLD ALTSLDFSHN
QIEVVCEPEL RPLQGKALSF LSLASNPLYI RVSVDWGACG NPLRNMTLET LDLSHNSWSV
ARVRNFSQAI RGSLVSSLLL SQHIMGPGFG FQNLQEPDQT TFAGLAGSSV KLLDLSGGYI
FSLNPRLFEA LWELKVLNLA HNKINKIADG TFQGLQNLQL LNMSYNLLGE LYNSDFSGLS
RVAYIDLQNN HIGIVQHQTF SLLKHLQTLD LQNNALKTIS FLPSIDMVLL GGNKLTALPS
NVQLTANFLQ LSENKLEHLA DLYFLLQIPR LQVLIVNQNR LSFCDPELSP SKNPSLEKLF
LSENMLQLAW ESQACWDMFR GLPGLQLLFL NNNYLSFLPP QVFSHLTALR VLSLHANRLT
ALSPGDLPAS LEVLDVSRNQ LLTPDPAVFS SLRFLDVTHN KFICECELGA FVTWLNCTNV
TLLGPPQDRY CVYPHWLEGV PLADLSVDCD DEEVLRALRF VLFSFLTVSL TLFLGTTLIV
ARFRGHCFVC YQKAQGLLFR DAGRAAEASG YRYDAYLCFS ARDFEWVQSA LLRHLDAQYS
PRNRLRLCFE ERDFVPGENH LANIQDAVWC SRKTVCVVSR HFLRDGWCLE AFSYAQSKCV
SDLSSALVVL VVGSLSQYQL MKHQALREFV RKRQYLRWPE DLQDVSWFLS KLSQHILKRE
KSRRTGEAQR REDSGVELHA VATPS
//
