ID   A0A1S3A703_ERIEU        Unreviewed;       674 AA.
AC   A0A1S3A703;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Gamma-adducin isoform X2 {ECO:0000313|RefSeq:XP_007530387.1};
GN   Name=ADD3 {ECO:0000313|RefSeq:XP_007530387.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530387.1};
RN   [1] {ECO:0000313|RefSeq:XP_007530387.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
CC       {ECO:0000256|ARBA:ARBA00006274}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_007530387.1; XM_007530325.2.
DR   AlphaFoldDB; A0A1S3A703; -.
DR   CTD; 120; -.
DR   OrthoDB; 45123at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR   InterPro; IPR001303; Aldolase_II/adducin_N.
DR   InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR   PANTHER; PTHR10672; ADDUCIN; 1.
DR   PANTHER; PTHR10672:SF5; GAMMA-ADDUCIN; 1.
DR   Pfam; PF00596; Aldolase_II; 1.
DR   SMART; SM01007; Aldolase_II; 1.
DR   SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          139..321
FT                   /note="Class II aldolase/adducin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01007"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..665
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  75744 MW;  F3BBC340F8B8B7EE CRC64;
     MSSDSSQGVI TTPPPPSMPY KERYFDRINE NDPEYLRERN MSPDLRQDFN MMEQRKRVTQ
     ILQSPAFRED LECLIQEQMK KGHNPTGLLA LQQIADYIMA NSFSGFTSSP LSLGMVTPIN
     DLPGVDTSSY VKGEKLSRCK LASLYRLVDL FGWAHLANSY ISVRISKEQD HIIIIPRGLS
     FSEATVSNLV KVNIIGEVVD QGSTNLKIDH TGFSPHAAIY STRPDVKCVV HIHTLATAAV
     SSMKCGILPI SQESLILGDV AYYDYQGSLD EQEERIQLQK VLGPSCKVLV LRNHGVVALG
     ETVEEAFHYI FNAQKACEIQ VKALAGAGGI DNLLVLDLQK FKAFTHTVAA AGGGGVNMSS
     HQKWKVGEIE FEGLMRTLDN LGYRTGYAYR HPLIREKPRH KSDVEIPATV TAFSFEDDTV
     PLSPLKYMAQ RQQREKTRWL NSPNTYMKVN VPEESRNGET SPRTKITWMK TEDSSKVSSG
     TPIKIEDPNQ FVPLNTNPNE VLEKRNKIRE QNRYDLKTAG PQSQLLAGIV VDKPPSTMQF
     EDDDQAPPAP PNPFSHLTER ELEEYKKTIE RKQQGLEENH ELFSKSFTSM DVPVMIMNGK
     DDVHDVEEEL AKRVSRLTTS TTIENIEITI QSPEKIEEVL SAEGSPSKSP SKKKKKFRTP
     SFLKKNKKKE KVEA
//