ID A0A1S3A7Y9_ERIEU Unreviewed; 386 AA.
AC A0A1S3A7Y9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ectodysplasin-A isoform X4 {ECO:0000313|RefSeq:XP_007530811.1};
GN Name=EDA {ECO:0000313|RefSeq:XP_007530811.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530811.1};
RN [1] {ECO:0000313|RefSeq:XP_007530811.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR RefSeq; XP_007530811.1; XM_007530749.1.
DR AlphaFoldDB; A0A1S3A7Y9; -.
DR GeneID; 103120353; -.
DR CTD; 1896; -.
DR OrthoDB; 5361136at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 250..380
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 71..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 40991 MW; 5B578CD1795B23F5 CRC64;
MGYPEVEHRE PLPATARLEP GSQGCVCRGA PARASEGNSC RLFMGFFGLS LALHLLTLCC
YLELRSELRR ERGVESRLGG PGTTGTSGTL ISSSGLDADG SITRNFGQSS PQQQQLGPGE
STVTQESQDS HQMALLNFFF PEEKSYSEEG SRHIHRNKRS KGSEGTDGPV KNKKKGKKAG
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG IQGPSGTTDK
AGTRENQPAV VHLQGQGSAI QVKNGGVLND WSRITMNPKV FKLHPRSGEL EVLVDGTYFI
YSQVYYINFT DFASYEVVVD EKPFLQCTRS IETGKTNYNT CYTAGVCLLK ARQKIAVKMV
HADISINMSK HTTFFGAIRL GEAPAS
//
