ID A0A1S3A840_ERIEU Unreviewed; 378 AA.
AC A0A1S3A840;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ectodysplasin-A isoform X6 {ECO:0000313|RefSeq:XP_007530813.1};
GN Name=EDA {ECO:0000313|RefSeq:XP_007530813.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007530813.1};
RN [1] {ECO:0000313|RefSeq:XP_007530813.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR RefSeq; XP_007530813.1; XM_007530751.1.
DR AlphaFoldDB; A0A1S3A840; -.
DR CTD; 1896; -.
DR OrthoDB; 5361136at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 242..372
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 71..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..222
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 40111 MW; 8D6A66CDAABE0129 CRC64;
MGYPEVEHRE PLPATARLEP GSQGCVCRGA PARASEGNSC RLFMGFFGLS LALHLLTLCC
YLELRSELRR ERGVESRLGG PGTTGTSGTL ISSSGLDADG SITRNFGQSS PQQQQLGPGE
STVTQESQDS HQMALLNFFF PEEKSYSEEG SRHIHRNKRS KGSEGTDGKK AGPPGPNGPP
GPPGPPGPQG PPGIPGIPGI PGTTVMGPPG PPGPPGPQGP PGIQGPSGTT DKAGTRENQP
AVVHLQGQGS AIQVKNGGVL NDWSRITMNP KVFKLHPRSG ELEVLVDGTY FIYSQVYYIN
FTDFASYEVV VDEKPFLQCT RSIETGKTNY NTCYTAGVCL LKARQKIAVK MVHADISINM
SKHTTFFGAI RLGEAPAS
//
