ID A0A1S3A8E0_ERIEU Unreviewed; 2338 AA.
AC A0A1S3A8E0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Probable G-protein coupled receptor 179 {ECO:0000313|RefSeq:XP_007531015.1};
GN Name=GPR179 {ECO:0000313|RefSeq:XP_007531015.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007531015.1};
RN [1] {ECO:0000313|RefSeq:XP_007531015.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR RefSeq; XP_007531015.1; XM_007530953.1.
DR STRING; 9365.ENSEEUP00000003410; -.
DR GeneID; 103120527; -.
DR CTD; 440435; -.
DR eggNOG; KOG4418; Eukaryota.
DR InParanoid; A0A1S3A8E0; -.
DR OrthoDB; 3430189at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR CDD; cd00054; EGF_CA; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF7; G-PROTEIN COUPLED RECEPTOR 179-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_007531015.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2338
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010346105"
FT TRANSMEM 371..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 373..622
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 748..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1393..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1796..1905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1965..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2045..2073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2093..2118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2158..2183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2231..2338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1088
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1825..1843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1855..1873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1977..2020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2049..2066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2101..2115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2268..2282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2294..2310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2338 AA; 253979 MW; 1CCC5495F653D5F7 CRC64;
MPSPVWGLLG CCLLCSWAPG EPRPLRSLLP MSPQVRVGFV PTQVPSERVE AALAFLYSGD
AQQLSGANCS QRYEAQGAGA RPGLPPVLRR AANTLTQAVN FLNLLLQAND IRESSIEEDV
EWYQALVRSV AEGDPKVYRA LLTFNRPPGA SHLQLALQAT RLGEETVLRD LSQSRVQEES
PTGAPETLAL QKRVLTNDLG SLDSPKWPRG DGYVSDMQHV RVSPPFLECQ GGQLHPGWLI
TLSATFYGLK PDLTPEVRGQ VQMDINLQSV DINQCASGPG WYSNTHLCDL NSTQCISLEG
QGFVLGHYLC HCRPGFYGAS HSGGLEENAV WLAGQFGSAL GGPGRLLRCL PCAEGCSSCM
DGTPCLVEEA LALRAAVLAC QASCMLAVFL SMLASYRCRR SKMIRASGVV LLETILFGSL
LLYFPVFILY FKPSVFRCIA LRWVRLLGFA IVYGTIILKL YRVLQLFLSP SAQRGPHLSS
GRLLRSLSLL LLLVLGFLAV WTAGTLERNQ HLPLVIRGHT PTGRHFYLCH HDRWDYIMVV
AEMLLLCWGS FLCYATRAVP SAFHEPRYMG VALHNELLLS AAFHAARFVL VPSLHPDWTL
LLFFFHTHST VTTTLALIFI PKFRKPGAPS REEMVDEVYE DELDLQCSGS YLNSSITSAW
SQRSLDPGDI RDELKKLYAQ LEVHKTKEMT ANNPHLPKKC GSSRQGLGRS FMRYLAEFPE
ALARQHSRDS GSLGHSSLPG SSRRWLLSSS LQEPEGPPGL RKSHSTYEHD HHREQDPPLL
DSLLKRKLAK KVSRESWESS VEGTPVLGFR SASAHNLTVG ERLPRARPTS LQKSLSVVAG
SREKALLVAS QTYLEETYRQ AKEQEERKKA EAAMASPVRG PSARRLERVR GAPLSAPPSP
AKSKSADSSH TSGKLQEEAG KRLPHPPIRH QVSTPTLALS GGACLGEPRM LSPTSTWTPA
LMPALAPALA AAPAPALAPA PAPALFPAPV LALAPVPVPP QSPSLLTYIC PWESVELPTK
KENAAQEGPT EPERDSLSPA PARARLWRAL SVAIERKGAG DNVMDTEDMR LQGDTDNTDE
DRPKVFSKSH SLKTPVQQGS VRSLGLAIKA LTRSRSSYRE KEREEATTEG NYKGGASEKG
TVMSPRSPKP GRPRAVSKQA ALSTCEDEES LQNQQNAYTS RMLRSCQQED GKGQEDRGRR
AGGEGKAEKA VKAALRQVRQ GTAGDKNSEQ VKEAPMGWQK PLPKVSQQSL RGADHSVAEV
CPWEAAEFEG QQSDSSKKAE ICPWEVSGGT PQSRVVRQER DGYWGEKEKD SEKPEPKGIA
AIAQKKPERL VRGQEAMCPW ENANSRDQSP QADRCQQEAT APEACAPAVA KAELCPWEET
VGGENGKASL QGVTELPQEK QKPPRKAPFW KDQTIISGDL ESICPWERTD FRGPSAVPDE
ASGTPGCSGS LDSSVKAGEA PAVRKAEICP WELGDRVTGE ERLTQGAEKE LLGKGSFEKT
REQTGQAVQK LNQSEEVVCP WESTAPGHPS PCLDNSSSRH SKGESIATKA CLQEDLRPEV
EDITPAKAEV CPWETDERTK GSWTSGQEPR SESPKDKEKI PAGFKDATDW GKSPGQIQTQ
EAVCPWEIVD PGSFTQQPGP QDIGRTRVSL QIASSVSSKA AEVCPWDTEE ALHAEKTEIC
PWEGTTGAGE GAGALGVEVI RKLKPNDLDS RSSKITVTVP KTPERPTQEW EVACPQEIVD
TRQPSTVDTE REKANFQELD YVGCKPAEVC PWEVEEASSG ETAKICPWEV SEGTAGEAAK
LNRSGSAEQR GKTLGQGGLA SLGEDKSKWE MKQSQEQEAI CPWEEDLRGP YAQGPQVSDP
SNSVSSNMAG THSLEVSEEA AEIGDQQQDP KMSEGRAEYT SQSKVLPSPA GNLIIVTTTD
GTKTAHKPQD SLVLAASFTH PDCECPELWE TSSQRPLSTG IQRAELLPGD TPTPGAHKSD
SRVKAEAHPR EVIERTSGEE VARDYRKGKS WEKGKGPEEL EHRAVAVQGK PERADGKQET
VCLWEGQDGR TVSPQTVPQA SDQREGSSEA VGGVGAKAAD ECLWEAAEAP SANKTEVCAW
EESEGAAEKG GLDQEVDGDS QGQAQLFLQK AGSRKTEEHT SKAAAKVSRE LGCPWEGLGS
GESFLQPGAP ANGQPKASLH RESSVGSKMA EVCQWEITDP EGNKLKGTME YICPWEGTGA
FAEETGLLAL RPIQTETATP TAPEKLPGLS VHRPSGSFLP ESKSPRPEAN QPAGTFTQES
VREFHGPSGL GAESSLTPEP TLQETEAHKC TPITGDQEEA ASTIHHKEPA PPTVSPWE
//