ID   A0A1S3A8F5_ERIEU        Unreviewed;       555 AA.
AC   A0A1S3A8F5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein {ECO:0000256|ARBA:ARBA00019443};
GN   Name=ITPRIP {ECO:0000313|RefSeq:XP_007531033.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007531033.1};
RN   [1] {ECO:0000313|RefSeq:XP_007531033.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC       triphosphate receptor (ITPR) Ca(2+) release.
CC       {ECO:0000256|ARBA:ARBA00003856}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus outer membrane
CC       {ECO:0000256|ARBA:ARBA00004494}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004494}.
CC   -!- SIMILARITY: Belongs to the ITPRIP family.
CC       {ECO:0000256|ARBA:ARBA00005554}.
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DR   RefSeq; XP_007531033.1; XM_007530971.2.
DR   AlphaFoldDB; A0A1S3A8F5; -.
DR   STRING; 9365.ENSEEUP00000006955; -.
DR   GeneID; 103120543; -.
DR   CTD; 85450; -.
DR   eggNOG; ENOG502QRDF; Eukaryota.
DR   InParanoid; A0A1S3A8F5; -.
DR   OrthoDB; 5299698at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.1410.40; -; 1.
DR   Gene3D; 3.30.460.90; -; 1.
DR   InterPro; IPR026250; ITPRIP-like.
DR   InterPro; IPR024810; Mab-21-like.
DR   InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR   PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR   PANTHER; PTHR10656:SF8; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN; 1.
DR   Pfam; PF20266; Mab-21_C; 1.
DR   PRINTS; PR02107; INOS145TPRIP.
DR   SMART; SM01265; Mab-21; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000313|RefSeq:XP_007531033.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..555
FT                   /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012887618"
FT   DOMAIN          428..485
FT                   /note="Mab-21-like HhH/H2TH-like"
FT                   /evidence="ECO:0000259|Pfam:PF20266"
FT   COILED          45..79
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   555 AA;  62890 MW;  5C6059744CA31670 CRC64;
     MALGLFRVCL VVVTAIINHP LLFPRENATV PENEEEIIRK MQVHQEMLQL EQLRLEEEVA
     RLVAEKEALE QVAEEGQQQN EARTSWDLWS TLCMILFLVI EVWRQDHQDG PSPECLGGDE
     DELPGLEGSP LRGLTLPNKA TLGHFYERCI RGATADAART REFVEGFVDD LLEALRSLGN
     RDKDLEVEDF IGVGSMYENW QADKPLLCEL LVPLTPPEPY HFHPELWCSH HSVPLDRHGY
     GQIKVAQADE DTPSCICDKT KLGEDMLCLL HGRNHLEQPG GGGDEVAGPL CAQDSPYLDT
     MQVMKWFQTA LTRAWHCIAH KYEFDLAFGQ LDTPGSLRIK FRSGKFMPFN LTPVIQFKGS
     DLYFVSHLPR QPSWGTPASS TDWLLSFAVY ERQFLRMTSK ALPEGACHLS CLQIASFLLS
     KQSRLTGPSA LGCYHLKTAL LHLLLTRRAV DWKAGQLDTR LHELLCFLEK SLLEKKLHHF
     FIGNHKVPEA MGIPEAVRRA EPLNLFRPFV LQRSLYRKTM DSFYEMLKNA PALISEYSLH
     LPTDHANLPP KAGVL
//