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Database: UniProt
Entry: A0A1S3A8M6_ERIEU
LinkDB: A0A1S3A8M6_ERIEU
Original site: A0A1S3A8M6_ERIEU 
ID   A0A1S3A8M6_ERIEU        Unreviewed;      1500 AA.
AC   A0A1S3A8M6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=rho GTPase-activating protein 35 {ECO:0000313|RefSeq:XP_007531026.1};
GN   Name=ARHGAP35 {ECO:0000313|RefSeq:XP_007531026.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae;
OC   Erinaceinae; Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007531026.1};
RN   [1] {ECO:0000313|RefSeq:XP_007531026.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   RefSeq; XP_007531026.1; XM_007530964.1.
DR   STRING; 9365.XP_007531026.1; -.
DR   GeneID; 103120539; -.
DR   CTD; 2909; -.
DR   OrthoDB; 110157at2759; -.
DR   Proteomes; UP000079721; Genome assembly.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000079721};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN      270    327       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      368    422       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      429    483       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      485    550       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      592    767       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      783    947       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1250   1437       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      970    989       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1060   1089       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1125   1148       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1449   1500       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      413    440       {ECO:0000256|SAM:Coils}.
FT   COILED      485    505       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    970    988       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1125   1140       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1449   1470       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1471   1487       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1500 AA;  170647 MW;  47DB968BC52C79CA CRC64;
     MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF HLDHTSVLST
     SDFGGRVVNN DHFLYWGEVS RSLEDCVECK MHIVEQTEFI DDQTFQPHRS TALQPYIKRA
     AATKLASAEK LMYFCTDQLG LEQDFEQKQM PDGKLLIDGF LLGIDVSRGM NRNFDDQLKF
     VSNLYNQLAK TKKPIVVVLT KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF
     STLVQLIDKS RGKTKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKNHNE NWLSVSRKMQ
     ASPEYQEYVY LEGTQKAKKL FLQHIHRLKH EHIERRRKLY LAALPLAFEA LIPNLDEIDH
     LSCIKTKKLL ETKPEFLKWF VVLEETPWDA TSHIDNMENE RIPFDLMDTV PAEQLYETHL
     EKLRNERKRA EMRRAFKENL ETSPFITPGK PWEEARSFIM NEDFYQWLEE SVYMEIYGKH
     QKQIIDRAKE EFQELLLEYS ELFYELELDA KPSKEKMGVI QDVLGEEQRF KSLQKLQAER
     DALILKHIHF VYHPTKETCP SCPACVDAKI EHLICSRFIR PSDRNQKNSL SDPNIDRINL
     VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS FQTPTFQPHG
     CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLVHLPLTL ILVNKRGDTS GETLHSLIQQ
     GQQIASKLQC IFLDPASAGI GYGRNINEKQ ISQVLKGLLD SKRNLNLVSS TASIKDLADV
     DLRIVMCLMC GDPFSADDIL YPVLQSQTCK SSHCGSSSSV LLELPIGLHK KRIELSVLSY
     HSSFSTRKSR LVHGYIVFYS AKRKASLAML RAFLCEVQDI IPIQLVALTD GAIDVLDNDL
     SREQLTEGEE IAQEIDGRFT SIPCSQPQHK LEIFHPFFKD VVDKKNIIEA THMYDNAAEA
     CSTTEEVFNS PRAGSPLCNS NLQDSEEDIE PPSYSLFRED TSLPSLSKDH SKLSMELEGN
     DGLSFIMSNF ESKLNNKVPP PVKPKPPVHF EMTKGDLSYL DQGHRDGQRK SVSSSTWLPP
     DGFDPSDYAE PIDAVVKPRN EEENIYSVPH DSTQGKIITI RNINKAQSNG SGNGSDSEMD
     TSSLERGRKV SLASKPVLYR TKCSRLGRFA SYRTSFTVGS DDELGPIRKK EEDQASQGYK
     GDNAVIPYET DEDPRRRNIL RSLRRNTKKP KPKPRPSITK ATWESNYFGV PLTTVVTPEK
     PIPIFIERCI EYIEATGLST EGIYRVSGNK SEMESLQRQF DQDHNLDLAE KDFTVNTVAG
     AMKSFFSELP DPLVPYNMQI DLVEAHKIND REQKLHALKE VLKRFPKENH EVFKYVISHL
     NKVSHNNKVN LMTSENLSIC FWPTLMRPDF STMDALTATR TYQTIIELFI QQCPFFFYNR
     PISELPGATP SSPSAMASTI PFLTSTPVTS QPSPPQSPPP TPQSPMQPLL PSQLQAEHTL
//
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