ID A0A1S3A9J4_ERIEU Unreviewed; 1785 AA.
AC A0A1S3A9J4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Pappalysin-2 {ECO:0000313|RefSeq:XP_007531530.1};
GN Name=PAPPA2 {ECO:0000313|RefSeq:XP_007531530.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007531530.1};
RN [1] {ECO:0000313|RefSeq:XP_007531530.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007531530.1; XM_007531468.1.
DR STRING; 9365.ENSEEUP00000010726; -.
DR CTD; 60676; -.
DR eggNOG; ENOG502QQ7Z; Eukaryota.
DR InParanoid; A0A1S3A9J4; -.
DR OrthoDB; 5483399at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR CDD; cd00033; CCP; 2.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF1; PAPPALYSIN-2; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00066; Notch; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 4.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1785
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010309960"
FT DOMAIN 1515..1587
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 74..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1785 AA; 197405 MW; C8B5895358BDC70A CRC64;
MTCVKALRIS LVILAGWALC TAGSEPRVSL DQRGPPAQLL SEGDHCWLGA KVRSLRASPQ
HHVFGVYPSR PGHYLQPYPR GHEGAPAAGH HKPDAQAKPG SLVAPAWSTE AEQPAGPWGG
VRQPQFPKDD ASSPDNGGPK ESLSNAGAPE DLATTSVHPK DPKIDTRGKF WTHPRYRRQT
AKQQASNVRG DLEIFAQQVP LGSQYLRVPR AHASPAPSEA TTLDTAAEGG MLWESEPLIP
HKGLPFLYFS GRREQLQLRP EALAEVPREA FTVEVWVKPE GGQHNPAIIT GVFDNCSHTV
NDKGWALGIR TAQDKGSEDA RFFFSLRTDR VKKATTVMGH HRYQAGMWTH LAATYDGKRM
TLYVDGTQVA SSADQSGSLH SPFMASCRFL LLGGDLSEDG HAFRGYLGTL VLWSSALPQS
HLQHGSWHPS ETAMLSSLIL TANFKLQEEQ WTPLREGGLP QLELLRGSVP QPQVVSPLQP
PRCGQTACDN VDLISQYNMH RPLWGKKVVR YQVVNICDDE GLNPMVSEQQ IQRQHQALEE
AFGRYNISWQ LHELRVRNST LRWRSVLVHC EPNKVGNDHC DSECNHPITG YDGGDCHLHS
RCYTSDLRDG HCQPECNNML NDFDEGDCCD PTVTSVRVTC FDPDSPRRAY MSVKELKEAL
RLNSTHFLNI YFASSAREDF MGSATWPWDK EALSHQGGVV LNPTYYGMPG HTNNMIHEMG
HILGLYHVFK GVSERESCDD PCQETEPSME TGDLCADTAP TPKSKLCQDP EPINDTCGFT
HFPGSPFNNY MSYTDDNCTD NFTPNQVARM HCYLDLVYQE WTESQKPTPI PMPPMVIRQT
PESLTIHWLP PISGVVYDRA PDNLCRACSE DGTFHQYVNK ASSPRVCDSS GYWTPEEAVG
TPDVDHPCEP SLQAWSPELH LYHMNMTVPC PSEGCSLEML FQHPVQANTL TLWVTYLSTD
SSRVLFDTEV LLENQKSVHL GPLDAFCDTP LTIKLNVEGK VLGVKVYTFD ERIEIDSALL
TSQPRSPLCS ACRPVSYQVL REPPFTSGSS MLVNHPHTKF TDMEVTPGQM YRYQVQAKAG
AELGEASPAL SHIHGGPFCS DGKVDRSLGE ECDDGDLLSG DGCSRSCKLE KGFNCAGDPS
LCYIYEGDGI CEPFEKETSL ADCGLYTPQG YLDQWATHAY SSHEDKKKCP VSLVTGEPHS
MICKPYPQDL AERHLLMGWF PCGTSGNRAQ DEQGEQPEGS LRRDREVWLK VSFNRPEVAT
AVFIFLTSVG LVPGKHRQPT VDLQLIDVNG NNHSLGTYEL SCQHNPLVVN MTLHPNVLFH
RTTSVLLKFS SPLVGISAVA LRTSSHPLGT SPPAPDSFNP GYQGENHQGQ GYANCIHREC
SVSVVPSCAP LLLDHSDIVN CTSDGPGHMK CTITCQRGFA LQATSGGHLK PLQKEMLFTC
SSGHWDRVMS CMPVNCGIPD PSLVNYATFS CSEGTGFLSR CSIACAPPAK LQGLSPWLTC
LEDGLWSLPE AFCKLECDAP PPIHNATLLQ PQCLQGSHDV GSICRYQCQP GYYTAGRTES
RESKIQSKFL EIQCLESGMW EQGSCSPVVC GRPSPIFEGM YECTNGFEFN SQCVLNCNQE
SERLSTFCTK EGVWSEEFKC ENLQGECPPV PSELNSVEYT CEERYGIGAV CSLTCLTPPS
DPVILPENIT LDTLQHWMEP VRVQSIVCTG RRQWYPDPFL VQCIKSCEPF QADGWCDTIN
NRAYCNYDGG DCCSSTLSSK KVTPFAADCD LEECTCRDPK AEENQ
//
