ID A0A1S3AA55_ERIEU Unreviewed; 420 AA.
AC A0A1S3AA55;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=COUP transcription factor 1 isoform X1 {ECO:0000313|RefSeq:XP_007531719.1};
GN Name=NR2F1 {ECO:0000313|RefSeq:XP_007531719.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007531719.1};
RN [1] {ECO:0000313|RefSeq:XP_007531719.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR RefSeq; XP_007531719.1; XM_007531657.2.
DR AlphaFoldDB; A0A1S3AA55; -.
DR GeneID; 103121150; -.
DR CTD; 7025; -.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; A0A1S3AA55; -.
DR OrthoDB; 5400963at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06958; NR_DBD_COUP_TF; 1.
DR CDD; cd06948; NR_LBD_COUP-TF; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083:SF168; COUP TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01282; COUPTNFACTOR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 80..155
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 181..407
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 45984 MW; 7A3FCBB3F512578D CRC64;
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGAGEQQQQ AGSGAPHTPQ TPGQPGAPAT
PGTAGDKGQG PPGSGQSQQH IECVVCGDKS SGKHYGQFTC EGCKSFFKRS VRRNLTYTCR
ANRNCPIDQH HRNQCQYCRL KKCLKVGMRR EAVQRGRMPP TQPNPGQYAL TNGDPLNGHC
YLSGYISLLL RAEPYPTSRY GSQCMQPNNI MGIENICELA ARLLFSAVEW ARNIPFFPDL
QITDQVSLLR LTWSELFVLN AAQCSMPLHV APLLAAAGLH ASPMSADRVV AFMDHIRIFQ
EQVEKLKALH VDSAEYSCLK AIVLFTSDAC GLSDAAHIES LQEKSQCALE EYVRSQYPNQ
PSRFGKLLLR LPSLRTVSSS VIEQLFFVRL VGKTPIETLI RDMLLSGSSF NWPYMSIQCS
//
