ID A0A1S3AA81_ERIEU Unreviewed; 503 AA.
AC A0A1S3AA81;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Thiamine transporter 1 {ECO:0000256|PIRNR:PIRNR028739};
DE Short=ThTr-1 {ECO:0000256|PIRNR:PIRNR028739};
DE AltName: Full=Solute carrier family 19 member 2 {ECO:0000256|PIRNR:PIRNR028739};
GN Name=SLC19A2 {ECO:0000313|RefSeq:XP_007531848.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007531848.1};
RN [1] {ECO:0000313|RefSeq:XP_007531848.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: High-affinity transporter for the intake of thiamine.
CC {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
CC Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC ECO:0000256|PIRNR:PIRNR028739}.
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DR RefSeq; XP_007531848.1; XM_007531786.2.
DR AlphaFoldDB; A0A1S3AA81; -.
DR GeneID; 103121266; -.
DR CTD; 10560; -.
DR eggNOG; KOG3810; Eukaryota.
DR InParanoid; A0A1S3AA81; -.
DR OrthoDB; 51626at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR028338; ThTr-1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF19; THIAMINE TRANSPORTER 1; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR PIRSF; PIRSF028739; Folate_carrier; 1.
DR PIRSF; PIRSF500794; Thiamine_transporter_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
KW Glycoprotein {ECO:0000256|PIRNR:PIRNR028739};
KW Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR028739,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 503 AA; 55599 MW; B0ACF8013C98745F CRC64;
MEAPGQGSRR SAAAAAAAAA AATMLLRPAR VPRECWPLPT ALLCAYGFLG SLRPSEPFLT
PFLLGPDKNL TAREVFNEIY PVWTYSYLVL LFPVFLATDY LRYKPVILLQ GLSLIVTWFM
LLYAQGLLAI QFLEFFYGIA TATEVAYYSY IYSVVDLNMY QKVTSYCRSA TLVGFTVGSI
LGQILVSVAG WSLFSLNVIS LTCVSVAFAV AWFLPMPQKS LFFHHIPSIC QGTNGIKVPN
GGIVPDTSAA NHLPGWEDIE SKIPLNVEEP PVDEPEPKPD RLLVLKVLWS DFRLCYSSRP
LLCWSVWWAL STCGYFQVVN YTQGLWEKVL PSRQAAIYNG GVEAVSTLLG AVAVFTVGYI
KISWSTWGEM TLSLFSLLIA AAVYIMDTVS NIWVCYASYV VFRIIYMLLI TIATFQIATS
LSMERYALVF GVNTFIALAL QTLLTLIVVD ASGLGLEISI QFLIYAGYFT FIAVVFLANG
AVSVMKKYRK PEDPEPSSQA TIS
//
