ID A0A1S3AA97_ERIEU Unreviewed; 651 AA.
AC A0A1S3AA97;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Aspartate--tRNA ligase, mitochondrial {ECO:0000313|RefSeq:XP_007531864.1};
GN Name=DARS2 {ECO:0000313|RefSeq:XP_007531864.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007531864.1};
RN [1] {ECO:0000313|RefSeq:XP_007531864.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Type 1 subfamily. {ECO:0000256|ARBA:ARBA00006303}.
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DR RefSeq; XP_007531864.1; XM_007531802.2.
DR AlphaFoldDB; A0A1S3AA97; -.
DR GeneID; 103121279; -.
DR CTD; 55157; -.
DR eggNOG; KOG2411; Eukaryota.
DR InParanoid; A0A1S3AA97; -.
DR OrthoDB; 1046261at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR CDD; cd00777; AspRS_core; 1.
DR CDD; cd04317; EcAspRS_like_N; 1.
DR Gene3D; 3.30.1360.30; GAD-like domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00044; Asp_tRNA_synth_type1; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004524; Asp-tRNA-ligase_1.
DR InterPro; IPR047089; Asp-tRNA-ligase_1_N.
DR InterPro; IPR002312; Asp/Asn-tRNA-synth_IIb.
DR InterPro; IPR047090; AspRS_core.
DR InterPro; IPR004115; GAD-like_sf.
DR InterPro; IPR029351; GAD_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR NCBIfam; TIGR00459; aspS_bact; 1.
DR PANTHER; PTHR22594:SF5; ASPARTATE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22594; ASPARTYL/LYSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF02938; GAD; 1.
DR Pfam; PF00152; tRNA-synt_2; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR PRINTS; PR01042; TRNASYNTHASP.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF55261; GAD domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|RefSeq:XP_007531864.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..651
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010287993"
FT DOMAIN 184..602
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 651 AA; 73690 MW; 8750407AFCE2A25D CRC64;
MHAAWWLGRL FLRLSRSAGS ARLTQGPGHR GLSSHRRDPE LSSFVARTNT CGELRSSHLG
QEVTLCGWIQ YRRQNMFLVL RDFHGLVQVV IPQDESAEAV KKILCDAPVE SVVQVCGTVI
SRPPGQENPK MPTGEIEIKV KKAEILNSCK RLPFEIKDFV KKTEAIRLQY RYLDLRSFQM
QHNLRVRSQM VMKMREYLCN LHGFVDIETP TLFKRTPGGA KEFVVPSREP GKFYSLPQSP
QQFKQLLMVG GLDRYFQVAR CYRDEGSRPD RQPEFTQIDI EMSFVDQIGI QSLIEGLLQY
SWPTDKDPVV VPFPSMTFAE AIASYGTDKP DTRFGMKIVD ISDVFRNTKI EFLQEALSKP
QGSVKAINIP KGIKYLKRKD IESIRKFATD HFNQEVLPVF LKANRNWNSP VAKIIVEEQS
QGLSRLMETQ EEDVVLLTAG EHNTACSLLG KLRLECADLL EARGVVIRDP ALFSFLWVVD
FPLFLPKEEE PGKLEAAHHP FTAPHPRDLH LLYTEPEKVR SQHYDLVLNG SEIGGGSIRI
HNAELQRYIL ATLLKEDVKL LSHLLQALDY GAPPHGGIAL GLDRLICLVT GASSIRDVIA
FPKSFRGHDL MSNAPDSVPP EELKPYYIQV SWPTDSEAAK ISLNHPHNPE K
//
