ID A0A1S3AAZ6_ERIEU Unreviewed; 383 AA.
AC A0A1S3AAZ6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
GN Name=DTYMK {ECO:0000313|RefSeq:XP_007532083.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007532083.1};
RN [1] {ECO:0000313|RefSeq:XP_007532083.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007532083.1; XM_007532021.2.
DR AlphaFoldDB; A0A1S3AAZ6; -.
DR STRING; 9365.ENSEEUP00000002566; -.
DR GeneID; 103121498; -.
DR CTD; 1841; -.
DR eggNOG; KOG3327; Eukaryota.
DR InParanoid; A0A1S3AAZ6; -.
DR OrthoDB; 5473102at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|RefSeq:XP_007532083.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000313|RefSeq:XP_007532083.1}.
FT DOMAIN 182..362
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 41141 MW; 7D86D2D9FD812474 CRC64;
MPALTTSRRR ADAGAEATPP GRAAATTGPV WLQAPGRPAV EGAAPGPVRT ARGGDTAPLS
PPGTEMGTRE AGLHPGRGET GTRLPEGGER ADADKDRTPT LGRSTVPPGS RGFLGVADTL
NRAAAERRQG VPANRIVIRG RGPVTPANRI ASSGRGPVAP ANRRAAAAAA AVMAARGALI
VLEGVDRAGK TTQSRRLVSA LCSAGHRAEL LRFPERSTEI GKLLGSYLEK KKEVEDHSVH
LLFSANRWEH VPLMKEKLQQ GITLVVDRYA FSGVAFTSAK ENFSLDWCKQ PDVGLPKPDL
VVFLHLHLAE AAARGEFGHE RYENRPFQER ALQRFQQLMG DPSLNWQMVD ASRSIEDVHK
EICKLSEETI RATAQTPLGT LWQ
//
