ID   A0A1S3AB04_ERIEU        Unreviewed;       541 AA.
AC   A0A1S3AB04;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=2-hydroxyacylsphingosine 1-beta-galactosyltransferase {ECO:0000313|RefSeq:XP_007532246.1};
GN   Name=UGT8 {ECO:0000313|RefSeq:XP_007532246.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007532246.1};
RN   [1] {ECO:0000313|RefSeq:XP_007532246.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   RefSeq; XP_007532246.1; XM_007532184.2.
DR   AlphaFoldDB; A0A1S3AB04; -.
DR   CTD; 7368; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   InParanoid; A0A1S3AB04; -.
DR   OrthoDB; 382054at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043:SF161; 2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        469..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   541 AA;  61549 MW;  4D79F133B2AF4E9A CRC64;
     MKSYTPYFML LWSALGIARA AKIIIVPPIM FESHMYIFKT LASALHEQGH RTVFLLSEGR
     DIAPSVHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA IELFDILDHY TKNCDMMVGN
     RALIQRLKKE KFDLLLVDPN DMCGFVIAHL LGVKYAVFST GLWYPAEVGA PAPLAYVPEF
     NSLLTDHMTL LQRMKNTGVY LISRLGVSFL VLPKYERIMQ KYNLLPEKSM YDLVHGSSLW
     MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPDDLQRWV NGANEHGFIL VSFGAGVKYL
     SEDIADKLAG ALGRLPQKVI WRFSGTKPTN LGNNTKLIEW LPQNDLLGHP NIKAFLSHGG
     LNSIFETMYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WKTVTEGELY EALVKVINNP
     SYRQRAQKLS EIHKDQPGHP VNRTVYWIDY ILRHNGAHHL RAAVHKISFW QYFLLDIAFV
     LLLGAALFYF LLSWATKFIY RKMTSLWSRN KHSAINGHYH NGILNGKYKR NGHIKHEKKV
     K
//