ID A0A1S3AB36_ERIEU Unreviewed; 625 AA.
AC A0A1S3AB36;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Protein artemis {ECO:0000256|ARBA:ARBA00039759};
DE AltName: Full=DNA cross-link repair 1C protein {ECO:0000256|ARBA:ARBA00042677};
GN Name=DCLRE1C {ECO:0000313|RefSeq:XP_007532138.2};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007532138.2};
RN [1] {ECO:0000313|RefSeq:XP_007532138.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007532138.2; XM_007532076.2.
DR AlphaFoldDB; A0A1S3AB36; -.
DR GeneID; 103121551; -.
DR CTD; 64421; -.
DR eggNOG; KOG1361; Eukaryota.
DR InParanoid; A0A1S3AB36; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd16297; artemis-SNM1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR PANTHER; PTHR23240:SF38; PROTEIN ARTEMIS; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 240..343
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
FT REGION 409..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 70928 MW; F317446CDDEBB47B CRC64;
MSSFEGQMAE YPTISIDRFD RENLRARAYF LSHCHKDHMK GLRAPALKRR LECSLKVYLY
CSPVTKELLL TSPKYRFWEK RIISIEIETP TQISLIDEAS GEKEEIVVTL LPAGHCPGSV
MFLFQGSNGT VLYTGDFRLA KGEAARMELL HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRG
ECLSGITELV RSWITRSPYH VVWLNCKAAY GYEYLFANLS EEFGVQVHVD KLDMFRNMPD
ILHHLTTDRG TQIHACRHPK AEEYFQWNKL PCGSTSRNGT PLHSISIKPS TMWFGERTRK
TNIIVRTGES SYRACFSFHS SYSEIKDFLS YICPVNAYPN VIPMGTTIDK VREILKPLCR
SLQNTEPKYK PLGKLKRAKI TYQDSEEEDD LFDDPLPPPL RYKVSKLQTS HPDTVPKTIG
FSSQPESPRR EGFKAERMQS SLWANFIDCE ESNSESEDEL QISPLSERDL GHQQKTEMEI
PQWEVFFKRK AADDGLGNGP SSTEAEGSQS PKLFSDSDGE STHISSQNSS QSTHISEQGS
QGWDSQSDTV LLSSQERNRP KIKEYIPASE TKENVPCPED TYTALKCRDQ YLNIAPSIGE
PTTLSSRKNI PQDKMVLNTS SSADS
//
