ID A0A1S3ABB0_ERIEU Unreviewed; 457 AA.
AC A0A1S3ABB0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Growth/differentiation factor 6 {ECO:0000313|RefSeq:XP_007532283.1};
GN Name=GDF6 {ECO:0000313|RefSeq:XP_007532283.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007532283.1};
RN [1] {ECO:0000313|RefSeq:XP_007532283.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007532283.1; XM_007532221.1.
DR AlphaFoldDB; A0A1S3ABB0; -.
DR GeneID; 103121690; -.
DR CTD; 392255; -.
DR eggNOG; KOG3900; Eukaryota.
DR InParanoid; A0A1S3ABB0; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd13766; TGF_beta_GDF5_6_7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF43; GROWTH_DIFFERENTIATION FACTOR 6; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..457
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010291594"
FT DOMAIN 334..457
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 29..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 50365 MW; 0006AC319400A9F8 CRC64;
MDTPRVLLCA VFLISFLWDL PGFQQASIAP SSSSAELGSA KGLRSRKDGK TPPREPRESR
TAGPPPAHPE TEALTRPPHP ESPGRGPRVV PHEYMLSIYR TYSIAEKLGI NASFFQSSKS
ANTITSFVDR GLDDLSHTPL RRQKYLFDVS TLSDKEELVG AELRLFRRAP PAPWGPPAGR
LRVQLFPCHS PQLLDARTLH PQGAPRAGWE VFDVWQGLRP RPGKLLCLEL RAAWAEPGAG
AQEAREAGAP HPAAPDLRSM GFGRRLRPSQ ERALLVVFTR SQRKNLFAEM REQLGSAEEA
AGAGADAGAP GSWPQPSGTP DIALGPWLPP AGRRLRRTAF ASRHGKRHGK KSRLRCSKKP
LHVNFKELGW DDWIIAPLEY EAYHCEGVCD FPLRSHLEPT NHAIIQTLMN SMDPGSTPPS
CCVPTKLTPI SILYIDAGNN VVYKQYEDMV VESCGCR
//
