ID A0A1S3AC92_ERIEU Unreviewed; 1016 AA.
AC A0A1S3AC92;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=DNA annealing helicase and endonuclease ZRANB3 isoform X1 {ECO:0000313|RefSeq:XP_007532761.1};
GN Name=ZRANB3 {ECO:0000313|RefSeq:XP_007532761.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007532761.1};
RN [1] {ECO:0000313|RefSeq:XP_007532761.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007532761.1; XM_007532699.2.
DR AlphaFoldDB; A0A1S3AC92; -.
DR STRING; 9365.ENSEEUP00000010258; -.
DR CTD; 84083; -.
DR OrthoDB; 318617at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd18010; DEXHc_HARP_SMARCAL1; 1.
DR CDD; cd00085; HNHc; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.30.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR002711; HNH.
DR InterPro; IPR003615; HNH_nuc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR45766:SF7; DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3; 1.
DR PANTHER; PTHR45766; DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF01844; HNH; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00507; HNHc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000313|RefSeq:XP_007532761.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_007532761.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000313|RefSeq:XP_007532761.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 1..148
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 265..421
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 594..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1016 AA; 116057 MW; F4D865E1CC3C7C3B CRC64;
MGLGKTIQAI AIAYFYKEEW PLLIVVPSSL RYPWSEEIEK WIPELGPKEI NVIQNKTDVW
RISSSKVTVL GYGLLTMDAE TLIDTLHNQN FKVVIVDESH YMKSRNATRS KILLPLVQKA
KRAILLTGTP ALGRPEELFM QIEALFPQKF GTWTDYAKRY CNARIRYFGK RTQWDYRGAS
NLKELHHLLS DIMIRRLKTQ VLTQLPPKIR QRIPFDLPSG AAKELSTSFE EWEKLMRAPS
SGATETVMGL ITRMFKQTAI AKAGAVKDYI KMMLQNESLK FLVFAHHLCM LQACTEAAIE
NKTRYIRIDG SVPSSERIHL VNQFQKDPDT RVAILSIQAA GQGLTFTAAT HVVFAELYWD
PGHIKQAEDR AHRIGQCSSV NIHYLIANGT LDTLMWGMLN RKAQVTGSTL NGRKEQIQAE
EGDKEKWDFL QFAEAWTPNE SFEELRNDIL FTHFEKEKQH DIRSFFLPKP NKRQLVTSCD
ESRTYQEKNT ISSANPGKIA IRDRVDCERN FEPETKRVKS VTSDGCCSSL EEKPSQLKET
KPPFSQGLCK ATTPPVSAEC WQCAFCTFIN NSLLPNCEMC ENPQSSAVLQ IDRHNNTQDQ
DKHEKDDSRK DTSKNMDTSS HCGKKVSVQS KSKLLAENNE EIPEVKEEDR LIPQLGNELK
NSNALPVYDT LMFCASKNTD RIHLYTKDGS QMNCNFIPLD IKLDLWEDLP ASFQLKQNRS
LILRFVREWS SLTAMKQRII RKSEQLFCSP ILALEEITKQ QAKQHSTKRY ITKEDVAVAS
IDKVKSDGGH VCLITKESRQ QDPSTKKFLE DGARVPFLNP SIDQTELTVG PSASKGYLQA
VDREGNPLCL HCQQPVCQAK REPKANGWDS RFCSLQCQEE FWIRSNNSYL RAKVFEIEHG
VCQQCHLNAQ ELFLRLRDAP KSQRKSLLDT TWTSKLSLEQ LNEMIRNPGE GHFWQVDHIK
PVSSGGGQCS LDNLQTLCTL CHRERTAKQA KDRNQMRRQS VASKYGSDIT RFLVKK
//
