ID   A0A1S3ACD7_ERIEU        Unreviewed;       871 AA.
AC   A0A1S3ACD7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   Name=MMS19 {ECO:0000313|RefSeq:XP_007532709.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007532709.1};
RN   [1] {ECO:0000313|RefSeq:XP_007532709.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBUNIT: Component of the CIA complex. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000256|RuleBase:RU367072}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   RefSeq; XP_007532709.1; XM_007532647.1.
DR   AlphaFoldDB; A0A1S3ACD7; -.
DR   CTD; 64210; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU367072};
KW   Cytoskeleton {ECO:0000256|RuleBase:RU367072};
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          2..153
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          396..823
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   871 AA;  96711 MW;  B58ED55FEB4325E2 CRC64;
     MQSREEELKG LGADFTFGFI QVMDGEKDPR NLLVAFRIVH DLISRDYSLG PFVEELFEVT
     SCYFPIDFTP PPNDPHGIQR EDLILSLRTV LASTARFAEF LLPLLIEKVD SEILSAKLDS
     LQTLNACCTV YGQKELKDFL PGLWTSIRRE VFQTASERVE TEGLAALHSL TACLSHSVLR
     ADAEDLLDSF LSNILQDCRH HLCEPDMKLV WPSAKLLQAA AGASARACDQ ITGNVLPLLL
     EQFHNHNQSN QRRTILEMIL GFLKLQQKWS SEDKDERPLC GFKDQLCSLV SMVLTDPSTQ
     LQLVGIRTLT VLGAQPGLLS SGDLELAVGQ LYRLSFLEDD SQNWAAALEA AGTLATLYPV
     AFSNHLVPKL AEELCVAESD MTRGDWPTKC SRHMRCLQML SAISTHPSIV KETLPLLLQH
     LYQLNRGNMV AGTSEVIAVC QSLQQVAEKC QQDRENCWYF HQTAVPFLLA MAVQASMPEK
     EQSVLRKVLL EEEVLVAMVS IIGSATTHLS PDFAAQSVDH IVPLFLDGNM SFLPENSFPC
     RFQPFQDGPL EQRRLVALLM AFVCSLPRNV EIPHLNQLMQ ELLELSCCPN CSFSSTAAAK
     CFAGLLNKQP AGQQLDEFLQ LAVEKVESGL SSESYRSQAF TLLLWVTKAL VLRYHPLSSY
     LTDRLMAHLS DPELGPAAAD GYSLLMSDCT DVLTRAGHAD VRIMYRQRFF TDNVPSLVEA
     FHAAPQDVKP NYLKGLSHVL NRLPKSVLLP ELPTLLSLLL EALSCADSVV QLSTLSCLQP
     LLLEAPQVMS LHVDTLVNKF LDLTSNPCMA VRISALQCMH ALTRLPTPVL LPYKPQVIRA
     LAKPLDDKKR LVRKEAVSAR GEWFLLGSPG S
//