ID A0A1S3AF75_ERIEU Unreviewed; 499 AA.
AC A0A1S3AF75;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=E3 ubiquitin-protein ligase TRIM69 {ECO:0000313|RefSeq:XP_007534170.1};
GN Name=TRIM69 {ECO:0000313|RefSeq:XP_007534170.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007534170.1};
RN [1] {ECO:0000313|RefSeq:XP_007534170.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007534170.1; XM_007534108.1.
DR AlphaFoldDB; A0A1S3AF75; -.
DR STRING; 9365.ENSEEUP00000009005; -.
DR GeneID; 103123460; -.
DR CTD; 140691; -.
DR eggNOG; KOG2177; Eukaryota.
DR InParanoid; A0A1S3AF75; -.
DR OrthoDB; 3453019at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16611; RING-HC_TRIM69_C-IV; 1.
DR CDD; cd15818; SPRY_PRY_TRIM69; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF286; E3 UBIQUITIN-PROTEIN LIGASE TRIM69; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 40..81
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 303..499
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 163..259
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 499 AA; 57332 MW; A0F209AAB084FFD3 CRC64;
MEVSSHTSTI NSENYTDVDD LVTQIPSKVQ IQDISTELHC PLCNDWFRDP LMLSCGHNFC
QACIQNFWKQ QAKETFCPEC KMLCPYSNCT FNLVLEKLVE KIKKLHSLKS HPQCPEHGEN
LKLFSKPDGK LICFQCKDAR LSAEQSKEFL LVSDAVSFFT EELNIHQGQL EATLKELQSL
KNMQKDAIAA YKENKLQLQQ HISLEFLKIH QFLHNKEKDI LNELREEGKA LSEEMEQNLN
ELQDQYLFAK EMLMRIQSQM DQQNSFDFLQ DITVLLDSLD KGMRALSPRE LISRKLNPGL
FRGPIQYMIW REMESTLSPG LSALTLDPKT AHPNLVLSKN RTSVWHGDIK QAIPDDPERF
DSSVAVLGSK GFTSGKWYWE VEVAKKTKWT VGVVRESIIR KGSCPLTPEQ GFWLLRLRNQ
TDLKALDFPS CSLKLTNNLN KVGIFLNYEG GQVSFYNAKT MTHIYTFSST FSEKVYPYFC
PCLNDGGENK EPLHILHPQ
//
