ID A0A1S3AFS6_ERIEU Unreviewed; 452 AA.
AC A0A1S3AFS6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Serine incorporator 2 {ECO:0000313|RefSeq:XP_007534228.1};
GN Name=SERINC2 {ECO:0000313|RefSeq:XP_007534228.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007534228.1};
RN [1] {ECO:0000313|RefSeq:XP_007534228.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TDE1 family.
CC {ECO:0000256|ARBA:ARBA00006665}.
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DR RefSeq; XP_007534228.1; XM_007534166.2.
DR AlphaFoldDB; A0A1S3AFS6; -.
DR GeneID; 103123509; -.
DR CTD; 347735; -.
DR eggNOG; KOG2592; Eukaryota.
DR InParanoid; A0A1S3AFS6; -.
DR OrthoDB; 53161at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR PANTHER; PTHR10383:SF22; SERINE INCORPORATOR 2; 1.
DR Pfam; PF03348; Serinc; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..452
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010164405"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 452 AA; 50459 MW; 31BF333B98674DF4 CRC64;
MGACLGACSL LSCASCLCGS APCILCSCCP SSPNSTISRL IFTIFLFLGV LVSIIMLSPG
VESQLHKLPW VCEEGAGTSI ILQGHIDCGS VLGHRAVYRM CFATAAFFFL FTLLMICVRS
SRDPRAAIQN GFWFFKFLIF VGITVGAFYI PDGSFSDAWF YFGVAGSFLF TLIQLVLFID
FAHSWNQRWL GKAEECDSRA WYAGLFFFTF LFYVLSIAAV ALMFIYYTHP GACYEGKVFI
SLNLTFCVSV SIVAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWLALSNVP DQKCNPHLLT
HFSNGTAPDG YETHWWDAPS IVGLIVFFLC TLFISLRSSD HPQVNSLMQT EECTPTLEAV
QQQQQLTACE GRAFDNEQES VTYSYSFFHF CLMLASLHIM MTLTNWYRPG EARKMISTWT
AVWVKICASW AGLLLYLWTL VAPLLLPNRD FS
//
