ID A0A1S3AGF8_ERIEU Unreviewed; 525 AA.
AC A0A1S3AGF8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Butyrophilin subfamily 1 member A1-like {ECO:0000313|RefSeq:XP_007534668.1};
GN Name=LOC103123935 {ECO:0000313|RefSeq:XP_007534668.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007534668.1};
RN [1] {ECO:0000313|RefSeq:XP_007534668.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000256|ARBA:ARBA00007591}.
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DR RefSeq; XP_007534668.1; XM_007534606.1.
DR AlphaFoldDB; A0A1S3AGF8; -.
DR STRING; 9365.ENSEEUP00000001555; -.
DR GeneID; 103123935; -.
DR eggNOG; ENOG502QSRZ; Eukaryota.
DR InParanoid; A0A1S3AGF8; -.
DR OMA; AHMELRW; -.
DR OrthoDB; 2943983at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd05713; IgV_MOG_like; 1.
DR CDD; cd15819; SPRY_PRY_BTN1_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR037958; SPRY/PRY_BTN1/2.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24100; BUTYROPHILIN; 1.
DR PANTHER; PTHR24100:SF145; BUTYROPHILIN SUBFAMILY 1 MEMBER A1; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 2.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..525
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010287996"
FT TRANSMEM 245..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 284..478
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 496..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 58824 MW; 64C2C32BD3AEF6F2 CRC64;
MGFSTNSYHS LCLLTLILLQ VTRLDSVYFD VIGPPGPILA IVGEDARLPC HLSPNMSAEH
MELRWFREVS SAALVYRDGQ QQEEEQMAEY LGRTTLVEDD INVGRVAMKI HGVKVADGGE
YRCFFRQNES YEEAIVNLKV AALGSDPHIS VEVQENGEIQ LKCTSVGWYP DPQVQWRTPE
GKTFPSTSES RIPDGEGLFT VAASVIIRDT SLENVSCCIQ NLLLGQNKEV GLTIPAPFFP
SLAPWMVIVV VFVTVLGLLS IGSIFFTWKL YKERSGMIKD KFSSKEKLLE ELKWKKATLH
AVDVTLDPDT AHPHLFLYED SKSVRLEDSR QKLPDKLERF DSWPCVLGRE TFTSGRHYWE
VEVGDRTDWA IGVCRENVMK KGFDPLTPEN GFWAVELYGN GYWALTSLRT PLLLAEPPHR
VGVFLDYESG NISFHNMTDG SLIYNFLNAS FSGPLRPLFC LWSSGKKPLT ICPITDGHEG
VTVIVDAKDF SKEIPLSPMG ENHASRDTDT LHSKLIPTQS NQGTV
//
