ID A0A1S3AHH8_ERIEU Unreviewed; 601 AA.
AC A0A1S3AHH8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Kelch repeat and BTB domain-containing protein 8 {ECO:0000256|ARBA:ARBA00021754};
GN Name=KBTBD8 {ECO:0000313|RefSeq:XP_007535210.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007535210.1};
RN [1] {ECO:0000313|RefSeq:XP_007535210.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
CC -!- SIMILARITY: Belongs to the KBTBD8 family.
CC {ECO:0000256|ARBA:ARBA00006736}.
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DR RefSeq; XP_007535210.1; XM_007535148.1.
DR AlphaFoldDB; A0A1S3AHH8; -.
DR STRING; 9365.ENSEEUP00000008738; -.
DR GeneID; 103124435; -.
DR CTD; 84541; -.
DR eggNOG; KOG4441; Eukaryota.
DR InParanoid; A0A1S3AHH8; -.
DR OrthoDB; 5472491at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0014032; P:neural crest cell development; IEA:InterPro.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd18274; BTB_POZ_KBTBD8; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR028764; BTB/POZ_KBTBD8.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF433; KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 49..117
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 68881 MW; C7BA732ED1A5CD83 CRC64;
MAASADLSKS SPTPNGIPSS ETASDAMDPF HACSILKQLK TMYDEGQLTD IVVEVDQGKT
FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIVGVEAES MDLVLNYAYT SRVVLTEANV
QALFTAASIF QIPSIQDQCA KYMISHLEPQ NSIGVFIFAD HYGHQELRDR SKEYIRKKFL
CVTKEQEFLL LTKDQLISIL DSDDLNVDRE EHVYESIVRW FEHEQNEREV HLPEIFAKCI
RFPLMEDTFI EKIPPPFAQA IAKSYIEKGP PSINGCTQRL GMTASEMIIC FDAAHKHSGK
KQTVPCLDIV TGRVFKLCKP PNDLREVGIL VSPDNDIYIA GGYRPSSSEV SIDHKAENDF
WMYDHSTNRW ISKPSLLRAR IGCKLVYCCG KMYAIGGRVY EGDGRNSLKS VECYDSRENC
WTTVCAMPVA MEFHNAVEYK EKIYVLQGEF FLFYEPQKDY WGFLTPMTVP RIQGLAAVYN
DSIYYIAGTC GNHQRMFTVE AYDVELNKWT RKKDFPCDES INPYLKLVLF QNKLHLFVRA
TQVTVEEHVF RTSRKNSLYQ YDDIADQWVK VYETPDRLWD LGRHFECAVA KLYPQCLQKV
L
//
