ID   A0A1S3AHQ6_ERIEU        Unreviewed;      1409 AA.
AC   A0A1S3AHQ6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Zinc finger FYVE domain-containing protein {ECO:0000256|PIRNR:PIRNR037289};
GN   Name=ZFYVE9 {ECO:0000313|RefSeq:XP_007535211.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007535211.1};
RN   [1] {ECO:0000313|RefSeq:XP_007535211.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037289}. Early
CC       endosome membrane {ECO:0000256|PIRNR:PIRNR037289}.
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DR   RefSeq; XP_007535211.1; XM_007535149.1.
DR   STRING; 9365.ENSEEUP00000009012; -.
DR   GeneID; 103124437; -.
DR   CTD; 9372; -.
DR   eggNOG; KOG1841; Eukaryota.
DR   InParanoid; A0A1S3AHQ6; -.
DR   OrthoDB; 3061552at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   CDD; cd15729; FYVE_endofin; 1.
DR   Gene3D; 3.30.500.40; -; 1.
DR   Gene3D; 3.30.1360.220; Domain of unknown function (DUF3480), N-terminal subdomain; 1.
DR   Gene3D; 4.10.720.10; Smad anchor for receptor activation, Smad-binding domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR022557; SARA-like_C.
DR   InterPro; IPR024608; SARA-like_SBD.
DR   InterPro; IPR035438; SARA/endofin.
DR   InterPro; IPR037145; SARA_Smad-bd_sf.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46319; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46319:SF2; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF11409; SARA; 1.
DR   Pfam; PF11979; SARA_C; 1.
DR   PIRSF; PIRSF037289; SARA/endofin; 2.
DR   SMART; SM01421; DUF3480; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SMART; SM01422; SARA; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037289};
KW   Endosome {ECO:0000256|PIRNR:PIRNR037289};
KW   Membrane {ECO:0000256|PIRNR:PIRNR037289};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRNR:PIRNR037289};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          683..742
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   REGION          199..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1409 AA;  154275 MW;  25CA23F3852D6635 CRC64;
     MENYFQAEAY NLDKVLDEFE QNEDETVPPI LLDTKWNKIV DSSSHRLSFN SALTSVSEPA
     APNESEPKLK VFSLAHSSPL STEEEDHSAN GQDCCLNPEV SAMWIDESVV AKDQLIKRNC
     NQDDQCSAVE VGENKCGNLA CLPDDKNVLV VAVMHNCDKR TLQSDLQDCN NYNSQNLMDA
     FSCSLDNENR QTDQFNLSIN GSTEKDMNSE KQMDPMPRPN TEGDSVKHLC TTSSDNLASI
     CSPLQLKDDE NIGRDPSTSG ISSVVVDSVI SSQVADEDSA GKKQEEVLMG KTGSPTPDLG
     SPNSFSHLNE EILMMEEPAE ERTIEESVQS GLLLKSDIPS GSGRDDYCGQ FSDSLMPSDE
     NKSCEPEEIL GTTDLNMTEH FSDSQEKTNW KLTKLNEMSD SQVNKENEKF VQMNQPEDTC
     NNNGECNRVA EANLDLKGTC MKESEGCDFS SATDTPAANP LSNCDSYGMQ SPVCFVPKTL
     PSKEDSVTEE KEIEESKSEC YSNIYEHRGN EGTEGSGLLL NSPGDLVKKN YSHNFCSQSP
     SMLGQSSPKI IANLQSISVP FGGARPKQPS NLKLQIPKPL SDHLQDLPAN SGNNIKNKND
     VLGKTKLGEN TATNICNTSL GTISIADTNG EHLESYEAGV SSRPCLALAP DSPDNDLRAG
     QFGISARKSF TTLGEVAPVW VPDSQAPNCM KCEARFTFTK RRHHCRACGK VFCASCCSVK
     CKLLYMDRKE ARVCVICHSV LMNAQAWENM MSASSQSPNP NNPAEYCSTI PPLQQAQASG
     ALSSPPPTVM VPVGVLKHPG AEVAQPREQR RVWFADGILP NGEVADATKL TTNGTSSAGT
     LAVSHDPVKP VTTSPLPAET DISLFSGSIT QVGSPVGSAM NLIPKDGLPP ILISTGVKGD
     YAVEEKPSQI SVMQQLEDGG PDPLVFVLNA NLLSMVKIVN YVNRKCWCFT TKGMHAVGQS
     EIIILLQCLP DEKCLPKDIF NHFVQLYRDA LAGNVVGNLG HSFFSQSFLG SKEHGGFLYV
     TATYQSLQDL VLPTPPYLFG ILIQKWETPW AKVFPIRLML RLGAEYRLYP CPLFSVRFRK
     PLFGETGHTI MNLLADFRNY QYTLPVVQGL VVDMEVRKTS IKIPSNRYNE MMKAINKSNE
     HVLAGGACFN EKADSHLVCV QNDDGNYQTQ AISIHNQPRK VTGASFFVFS GALKSSSGYL
     AKSSIVEDGV MVQITAENME ALRQALREMK DFTITCGKAD AEDPQEQIHI QWVDDDKNVN
     KGVISPIDGK SMESITSVKI FHGSEYKANG KVIRWTEVFF LENDDQHSCL SDPADHSRLT
     EHVAKAFCLA LCPHLKLLKE DGMTKLGLRV TLDSDQVGYQ AGSNGQPLPS QYMNDLDSAL
     VPVIHGGACQ LSEGPIVMEL IFYILENIA
//