ID A0A1S3AJ08_ERIEU Unreviewed; 1273 AA.
AC A0A1S3AJ08;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ras GTPase-activating protein nGAP isoform X3 {ECO:0000313|RefSeq:XP_007535817.1};
GN Name=RASAL2 {ECO:0000313|RefSeq:XP_007535817.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007535817.1};
RN [1] {ECO:0000313|RefSeq:XP_007535817.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007535817.1; XM_007535755.2.
DR AlphaFoldDB; A0A1S3AJ08; -.
DR GeneID; 103124989; -.
DR CTD; 9462; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 74..304
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 295..413
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 473..665
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1120..1186
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 160..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1273 AA; 143518 MW; 1C3393AA5A967557 CRC64;
MELSPSSGGA AEALSWPELF PGPEADSPLP PEELDTAVPV SGATGGMLDR ILLESVCQQQ
SWVRVYDVKG PPTHHLSCGQ SPYTDTTTWE RKYCILTDSQ LVLLNKEKEI PLEGQEQQTD
STKGRCLRRT VSVPSEGQFP EYPPEGTTKL EVPAERSPRR RSISGTSTSE KPNCMDTANT
SPFKVPGFFS KRLKGSIKRT KSQSKLDRNT SFRLPSLRNT DDRSRGLPKL KESRSHESLL
SPCSAVECLD LGRGEPVSVK PLHSSILGQD FCFEVTYLSG SKCFSCNSAS ERDKWMENLR
RTVQPNKDNC RRAENVLRLW IIEAKDLAPK KKYFCELCLD DTLFARTTSK TKADNIFWGE
HFEFYSLPSI HSITVHIYKD VEKKKKKDKN NYVGLVNIPT ASVTGRQFVE KWYPVSTPTP
NKGKTGGPSI RIKSRFQTIT ILPMEQYKEF AEFVTSNYTM LCSVLEPVIS VRNKEELACA
LVHILQSTGR AKDFLTDLVM SEVDRCGEHD VLIFRENTIA TKSIEEYLKL VGQQYLHDAL
GEFIKALYES DENCEVDPSK CSSSELIDHQ SNLKMCCELA FCKIINSYCV FPRELKEVFA
SWKQQCLNRG KQDISERLIS ASLFLRFLCP AIMSPSLFNL MQEYPDDRTS RTLTLIAKVI
QNLANFAKFG NKEEYMAFMN DFLEHEWGGM KRFLLEISNP DTISNTPGFD GYIDLGRELS
VLHSLLWEVV SQLDKATVAK LGPLPRVLAD ITKSLTNPTP IQQQLRRFTE HNSSPNVSGS
LSSGLQKIFE DPTDSDLHKL KSPSQDNTDS YFRGKTLLLV QQASSQSMTY SEKDEKESSL
PNGRSISLMD LQDTHASQME HASVMLDVPM RLTGSQLSIT QVASIKQLRE TQSTPQSAPQ
VRRPLHPALN QPLSFQNPVY HLNNPIPAMP KASVDSSLEN LSTASSRSQS NSEDFKLSGP
SNSSMEDFTK RSTQSEDFSR RHTVPDRHIP LVLPRQNSTG QAQIRKMDQT GLGARAKAPP
SLPHSASLRS TESMSVVSAA LVAEPVQNGS RSRQQSSSSR ESPVPKVRAI QRQQTQQVQS
PVDSATMSPV ERTAAWVLNN GQYEEDVEET EQNPDEAKHA EKYEQEITKL KDRLRVSSRR
LEEYERRLLV QEQQMQKLLL EYKARLEDSE ERLRRQQEEK DSQMKSIISR LMAVEEELKK
DHAEMQAVID AKQKIIDAQE KRIMSLDSAN TRLMSALTQV KERYSMQVRN GISPTNPTKL
SITENGEFKN SSC
//
