ID   A0A1S3AJM3_ERIEU        Unreviewed;       275 AA.
AC   A0A1S3AJM3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Cerberus {ECO:0000313|RefSeq:XP_007536120.1};
GN   Name=CER1 {ECO:0000313|RefSeq:XP_007536120.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007536120.1};
RN   [1] {ECO:0000313|RefSeq:XP_007536120.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|PIRNR:PIRNR027807}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC       ECO:0000256|PIRNR:PIRNR027807}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR   RefSeq; XP_007536120.1; XM_007536058.1.
DR   AlphaFoldDB; A0A1S3AJM3; -.
DR   STRING; 9365.ENSEEUP00000001325; -.
DR   GeneID; 103125281; -.
DR   CTD; 9350; -.
DR   eggNOG; ENOG502S2G4; Eukaryota.
DR   InParanoid; A0A1S3AJM3; -.
DR   OrthoDB; 5347549at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0003002; P:regionalization; IEA:UniProt.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR016860; Cerberus.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   PANTHER; PTHR15273:SF4; CERBERUS; 1.
DR   PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF027807; Cerberus; 1.
DR   SMART; SM00041; CT; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Secreted {ECO:0000256|PIRNR:PIRNR027807};
KW   Signal {ECO:0000256|PIRNR:PIRNR027807}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT   CHAIN           18..275
FT                   /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT                   /id="PRO_5024527281"
FT   DOMAIN          164..248
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|PROSITE:PS01225"
SQ   SEQUENCE   275 AA;  31333 MW;  79AB39FE3410D079 CRC64;
     MHLFLFQLLV LLPQGKAAWH KGGHQRSSLV SLLHPDRNRR ELSRDNQEEA QEKPDLFVAV
     PHLIGVGAAV NDQRQREKML SRFGRFWKKP EGILSPTPDS SELFSSFSSV PQDLPQSKDD
     MQMEKTLLPE EARKFWHHFM FRMSPASQGV ILPIKSHEVH QETCRTVPFS QAVTHEDCEK
     VIVQNNLCFG KCGSVNFPGA AQQHQTFCSH CLPTKFTKMH LPLNCTDFAP VVKVVMLVEE
     CQCKVKTEHE HGHLFQDGSR AEFHVQDPFI PGFST
//