ID A0A1S3AL28_ERIEU Unreviewed; 2741 AA.
AC A0A1S3AL28;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Mucin-5AC {ECO:0000313|RefSeq:XP_007536647.1};
GN Name=MUC5AC {ECO:0000313|RefSeq:XP_007536647.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007536647.1};
RN [1] {ECO:0000313|RefSeq:XP_007536647.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR RefSeq; XP_007536647.1; XM_007536585.1.
DR CTD; 4586; -.
DR eggNOG; KOG1216; Eukaryota.
DR InParanoid; A0A1S3AL28; -.
DR OrthoDB; 2872912at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR CDD; cd19941; TIL; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF404; MUCIN-5AC; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF13330; Mucin2_WxxW; 3.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 3.
DR SMART; SM00041; CT; 1.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..2741
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010251707"
FT DOMAIN 77..249
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 432..607
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 901..1071
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1655..1839
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2268..2337
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2376..2443
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2525..2613
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1315..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1355..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1555..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2000..2026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2141..2232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2616..2706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1315..1339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1412
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1555..1583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2141..2229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2673..2696
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2525..2575
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 2741 AA; 294206 MW; 0F1F519D1CC70633 CRC64;
MGVGRRMLGP LWVLALALAC AQHAGLALDS PTEHSHFLDL PPVPQGPAGE PVRGVTILPP
MRTVPVIRAL NPAHNGRVCS TWGDFHYKTF DGAIFRFPGL CNYVLSAHCG AAYEDFNLQV
RRCDPATTVT TSVCGVTLKL DGMVVGLTGK SVLVNGAPVQ LPFSRSGVSI ELGSGYVKVA
ARLGLVFMWN QDGSLLLELD PKYANQTCGL CGDFNGLPDL NEFFVHGARV SPVEFGNLQK
MDGPTEQCQD PVPAPLQNCS TNATLCEETL SGPLFSGCAR LVDASSYVEA CRRDLCACRE
EDPSRCGCHT LAEYARQCAH AGGRPRDWRG PQLCAAQCPA GMQHRECGSP CADTCSNPER
AQLCEDHCVA GCFCPEGTVL DDIGHSGCVP MAQCPCTHNG ITFAPGTGYA TDCTNCTCSA
GRWGCRERPC PGTCAVLGGA HISTFDERHY TVHGECGYVL AKPCTGSAFS VLAELRRCGL
TASETCLKSV TLSLDGGHLV VEVKASGEVF VNQMFTQLPV STANITLLRP STFFVVVHTE
LGLQLDVQLV PTMQVFLRLE PRLRGLTCGL CGNFNQNQGD DFRALSGVVE GTAAAFANTW
KAQANCPNVR NSYEDPCALS VENEKYAQHW CSRLTDPQGP FASCHEAVNP SVYYSNCMFD
TCNCEKTEDC LCAALSSYVR ACASRGVLLQ GWRAGVCAKP LTACPKSLKY EYNVSSCQPT
CRSRAGQDAS CGVRFVPVDG CVCPQGTFLD DTGKCVPATS CPCYHGSSVV PNGETLHEGG
AICTCTQGSL SCIGGQTSAP VCAPPMVYFA CRNATPGAAG AGCQKSCHTL DMECYSPQCV
SGCVCPDGLV ADGLGSCVSA DDCPCVHNEA SYQTGQTIRV DCNTWYGEHR HWECTKEPCM
ATCAVYGDGH YITFDGHRYS FSGDCQYTLL QDQCGGNSSS RDGFRVITEN VPCGTTGTTC
SKAIKIFLGS SELRLSDGQV EVLEKGAGPP TYSIRQMGLY LVLDTEAGLL LLWDKKTSLL
LRLEPRFKGR VCGLCGNFDD NGLNDFTTRS QSVAGSAREF GNSWKFSPTC PDAPAPRDPC
SANPYRKAWA QRQCSIINGA PFAACRAHVE PTPYYEACVS DACACDSGGD CECFCTAVAA
YAQACHDAGI CVSWRTPDIC PLFCDYYNPE GQCEWHYQPC GAPCLRTCRN PSGRCLHDLQ
GPEGCYPKCP PEAPIFDEDG MQCVTTCPTP TPAPLCRVQG RTYRPGAAVP SEQNCHSCVC
TEAGVQCSYD KDACVCTYGG QHFRPGEVIY QTTDGTGGCI SAQCGPDGSI QRRVSPCGPS
TQAPQTTFSF STPPQGEQTG LGTGVMGALR EGTGRELHTP TDHARQLHSN DCHQDHGHPK
SSILTHAHIH THHNPHIHYN RHANHNPHIH YNRHSNHNPP IHYNRHHISQ LECRAESHPG
VSLGDLGQVV QCSPDVGLVC RNQDQTGRFQ MCLNYQVRVR CCQLPPSGCP LSSQTPSVSP
EPSTSATIPT SRPCYCSISG QLFPAGSVIY QESDLDGHCY YAVCSLDCHV VRGTDSSCPR
STSAPTSRAT SRPETSASSP VSVPVPGCPS AVPPRARGET WAMPNCSQAT CEGDNVISVG
RRPCPQLTPP TCANGYPALL EADQDGCCKH YQCQCVCSGW GDPHYITFDG TYYTFLDNCT
YVLVQQVVPV FGHFRVLIDN YFCDSADGLS CPQSITVEFR QHRVELTRRA VQGVMTNQIL
FDGAVVSPGF RAGGLAVSQI GVKMYVTVPE LGVQVMFTGL IFSVEVPFSK FANNTEGQCG
TCTDNRLDDC RLPGGAVVTS CSDMSRHWKV TTPGQPSCHG PPPAPTTWPT TPPTPCLPSA
VCHLILSNEP RDPAHCPLTP SEPRDPAHCP LTPSKLGSGD QDCQWSPWLD VSWPGLGPDS
GDFDTLDNLR AHGHRLCQAP RAVQCRAEDA PGEPLEALGQ RVQCSPEVGL TCHNRDQASG
RCYNYQIRVL CCTPRACTPA PPTTSRTTPT GPTSLVPTAT SGSTWVSSES TNKVSCVQQR
CSWTDWLDAS YPQPSMDGGD FDTFQNLRAK GFRFCARPSA VECRAQFFPD TPLAALGQDV
VCDTQVGLLC LNKDQLPPIC YNYAIRIQCC EPVDVCHGTG VPSGSPSTSL PTHPTTTTTA
STPVTRVPET PDTSSGVPYI LSPSTTMAST ASSPSTTSSA HTSVTSHHPS TGPPETMTPK
TTPTPQGLVT SPHRALPYAG LITEGCFCPA GTMPFSSTSD VCVPTDCQGC LGPHGELVEP
GHVVTEDCQQ CSCEAGSRTL SCRPLACPLP PACPNPGFVP VPVTPQDGQC CPYYNCACNA
SHCPVLGDCP HGFRPVQTHE EGACCPSQVC VPTKPPGCSV NGTLYQPGAV VFRNLCETCV
CVAPGGPEAD TYMVTCETQI CNTHCPMGYE YQVPSGQCCG HCVQVACVVN GSDGSPRLFL
PGATWPEPGD RCVTHECERH QDGLEVVTTR KACPPLSCPE SQAQLSEDGC CRFCPPPRHD
NSSSCAIFHK HQVIRRDGCS SGSPVQLSFC RGNCGDTASM YSPKADAVRH HCRCCRELRV
SRLSVALSCP DGSRRTVSLA QPTECGCQGL RCDPQDTSSQ EQSQELWGPP PHEPRDPAYC
PLTHSEPRDP AHYPLTPSEP RDQAHCPLTP SEPRDPAYCP LTPSEPRDPA YCPLTPSEPR
DPAHCRKPLD ALRNRDANVQ TVTGWGGRSL KTSNRRTRRR R
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