ID A0A1S3AM38_ERIEU Unreviewed; 154 AA.
AC A0A1S3AM38;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Prefoldin subunit 2 {ECO:0000313|RefSeq:XP_007537470.1, ECO:0000313|RefSeq:XP_016049929.1};
GN Name=PFDN2 {ECO:0000313|RefSeq:XP_007537470.1,
GN ECO:0000313|RefSeq:XP_016049929.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007537470.1};
RN [1] {ECO:0000313|RefSeq:XP_007537470.1, ECO:0000313|RefSeq:XP_016049929.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC transfers target proteins to it. Binds to nascent polypeptide chain and
CC promotes folding in an environment in which there are many competing
CC pathways for nonnative proteins. {ECO:0000256|ARBA:ARBA00024667}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000256|ARBA:ARBA00008045}.
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DR RefSeq; XP_007537470.1; XM_007537408.2.
DR RefSeq; XP_016049929.1; XM_016194443.1.
DR STRING; 9365.ENSEEUP00000003174; -.
DR GeneID; 103126496; -.
DR CTD; 5202; -.
DR eggNOG; KOG4098; Eukaryota.
DR OrthoDB; 178677at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 1.10.287.370; -; 1.
DR InterPro; IPR027235; PFD2.
DR InterPro; IPR002777; PFD_beta-like.
DR InterPro; IPR009053; Prefoldin.
DR PANTHER; PTHR13303; PREFOLDIN SUBUNIT 2; 1.
DR PANTHER; PTHR13303:SF0; PREFOLDIN SUBUNIT 2; 1.
DR Pfam; PF01920; Prefoldin_2; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 30..121
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 154 AA; 16637 MW; 009FB23FFC1E919B CRC64;
MADGSGRAGK TSSSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME LNEHSLVIDT
LKEVDDTRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI IETLTQQLQA KGKELNEFRE
KHNIRLMGED EKPTAKENSE GAGAKASSAG VLVS
//
