ID A0A1S3AMA3_ERIEU Unreviewed; 665 AA.
AC A0A1S3AMA3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PAK6 {ECO:0000313|RefSeq:XP_007537392.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007537392.1};
RN [1] {ECO:0000313|RefSeq:XP_007537392.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007537392.1; XM_007537330.2.
DR AlphaFoldDB; A0A1S3AMA3; -.
DR GeneID; 103126426; -.
DR CTD; 56924; -.
DR eggNOG; KOG0578; Eukaryota.
DR InParanoid; A0A1S3AMA3; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06659; STKc_PAK6; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR035066; STKc_PAK6.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF19; SERINE_THREONINE-PROTEIN KINASE PAK 6; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|RefSeq:XP_007537392.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000313|RefSeq:XP_007537392.1}.
FT DOMAIN 12..25
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 391..642
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 420
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 665 AA; 72533 MW; 2D1ACE42B9E56BB7 CRC64;
MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT
RVQLQPMKTV VRGSSMPTDG YITGLLHDLQ KLSVTSSNTL RGRSPASRRR AQSLGLLGEE
HWGADPDMYL QSPQSERTDP HGLYLGCNGG APAGHREGPQ SPCALSNGGL AAKAQSLGPT
EFQGVGRCLQ LGACLQSPPP VTSPPAAPGR RGTKAARPGA EETRPQSCLV GSGRLGGEGS
PSPKAQENSL KRRLFRSMFL STPAAAPPGA PPQSKPAASR PSQKDPPPGQ VAKAQSLPAD
PPAGAFSPLP ASATSSPQKA PRTAPAAGRS SPAGSPRTRH PQISTSNLYL PQDPAAPRGA
PASEDPGVVT HEQFKAALRM VVDQGDPRRL LDSYVKIGEG STGIVCLARE RHSGRQVAVK
MMDLRKQQRR ELLFNEVVIM RDYHHLNVVE MYKSYLVGEE LWVLMEFLQG GALTDIVSQV
RLNEEQIATV CEAVLQALAY LHAQGVIHRD IKSDSILLTL DGRVKLSDFG FCAQISKDVP
KRKSLVGTPY WMAPEVISRS LYATEVDIWS LGIMVIEMVD GEPPYFSDSP VQAMKRLRNS
PPPRLKNSHK VSPVLRDFLD RMLVRNPQER ATAQELLDHP FLLQTGLPEC LVPLIQLYHK
QTSSC
//
