ID A0A1S3AN42_ERIEU Unreviewed; 835 AA.
AC A0A1S3AN42;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protein diaphanous homolog 2 {ECO:0000313|RefSeq:XP_007537819.1};
GN Name=DIAPH2 {ECO:0000313|RefSeq:XP_007537819.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007537819.1};
RN [1] {ECO:0000313|RefSeq:XP_007537819.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR RefSeq; XP_007537819.1; XM_007537757.1.
DR AlphaFoldDB; A0A1S3AN42; -.
DR STRING; 9365.ENSEEUP00000010094; -.
DR CTD; 1730; -.
DR eggNOG; KOG1924; Eukaryota.
DR InParanoid; A0A1S3AN42; -.
DR OrthoDB; 1118745at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 1..340
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 505..835
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 412..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..493
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 835
FT /evidence="ECO:0000313|RefSeq:XP_007537819.1"
SQ SEQUENCE 835 AA; 95453 MW; B97A4751CD42C5D5 CRC64;
MVTGSIPLKI TIKSMPFRLY HKRKLGGLKN SKHECTLSSQ EYVHELRSGI SDEKLLNCLE
SLRVSLTSNP VSWVNNFGHE GLGLLLDVLE KLLDKKQQEN IDKKNQYKLI QCLKAFMNNK
FGLQRILGDE RSLLLLARAI DPKQPNMMTE IVKILSAICI VGEENILDKL LGAITTAAER
NNRERFSPIV EGLENHETLQ LQVACMQFIN ALVTSPYELD FRIHLRNEFL RSGLKTMLPE
LKEKENDELD IQLKVFDENK EDDLTELSHR LNDIRTEMDD MNEVYHLLYN MLKDTAAENY
LLSILQHFLL IRNDYYIRPQ YYKIIEECVS QIVLHCSGMD PDFKYRQRLD IDLTHLIDSC
VNKAKVEESE QKAVEFSKKF DEEFTARQEA QAELQKREEK IKELETEIQQ LRNQEHELSS
ASRILGLPPP PQLPGSGLSP PPPPPPPPLP GGVLPPPPPP LPPSVAGIPP PPPPPLFGGP
PPPPPLGGGL PPPVLPPELP YGMKQKKLYK PEVSMKRINW SKIEPKDLSE SCFWLKAKED
KFENSDLFAK LALNFATQMK VQKNVETVEE KKTMPAKKKV KELRVLDPKT AQNLSIFLGS
YRMPYEDIKN IILEVNETML NEALIQNLVK HLPEQKVLNE LAQLKNEYDD LCEPEQFGVV
MSSVKMLRPR LNSILFKLTF EEHVNNIKPS IIAVTLACEE LKKSEGFNRL LELVLLVGNY
MNSGSRNAQS LGFKITFLCK IRDTKSSDQK TTLLHFIAEI CEEKYRDILK FPEELEHVES
ASKVSAQILK SNLAAMEQHI IHLEGDLKKF PQAENPKDKF VEKMTISFIY LRILF
//
