ID A0A1S3AN43_ERIEU Unreviewed; 583 AA.
AC A0A1S3AN43;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Numb-like protein isoform X2 {ECO:0000313|RefSeq:XP_007537973.1};
GN Name=NUMBL {ECO:0000313|RefSeq:XP_007537973.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007537973.1};
RN [1] {ECO:0000313|RefSeq:XP_007537973.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007537973.1; XM_007537911.2.
DR AlphaFoldDB; A0A1S3AN43; -.
DR GeneID; 103126979; -.
DR CTD; 9253; -.
DR eggNOG; KOG3537; Eukaryota.
DR InParanoid; A0A1S3AN43; -.
DR OrthoDB; 2913102at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR010449; Numb_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF4; NUMB-LIKE PROTEIN; 1.
DR Pfam; PF06311; NumbF; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 78..203
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..545
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 62014 MW; D51FB72253D13AF7 CRC64;
MSRSAAASGG PRRPEQHLPP APCGAPGPPE TFRTEPDGAG TMNKLRQSLR RRKPAYVPEA
SRPHQWQADE DAVRKGTCSF PVRYLGHVEV EESRGMHVCE DAVKKLKAMG RKSVKSVLWV
SADGLRVVDD KTKDLLVDQT IEKVSFCAPD RNLDKAFSYI CRDGTTRRWI CHCFLALKDS
GERLSHAVGC AFAACLERKQ RREKECGVTA AFDASRTSFA REGSFRGRPA EREAPDKKKA
EAAAAPTAAP GPAQPGHVSP TPATTSPGEK GEAGTPVAAG TSAAAIPRRH APLEQLVRQG
SFRGFPALSQ KNSPFKRQLS LRLNELPSTL QRRTDFQVKG TVPEMELPGA SDSDGINALC
TQISSSFASG GAPASGPPPA SAGASAWCES TGAPAAFQPG HRRTPSEAER WLEEVSQVAK
AQQQQQQQQQ VSALPAVTPA PPALQPFPAT GPFDTTPAQV AVFLPPAPMQ PPFVPAYPGL
GYPPMPRVPV VGITPSQMVA NAFCSAAQLQ PQPAALLGKA GAFPPAPRPR PNGAPWPPEP
APASAPELDP FEAQWAALEG KPSAEKPSNP FSGDLQKTFE IEL
//
