ID   A0A1S3AR63_ERIEU        Unreviewed;       417 AA.
AC   A0A1S3AR63;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Serine protease hepsin {ECO:0000313|RefSeq:XP_007539549.1};
GN   Name=HPN {ECO:0000313|RefSeq:XP_007539549.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007539549.1};
RN   [1] {ECO:0000313|RefSeq:XP_007539549.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007539549.1; XM_007539487.2.
DR   AlphaFoldDB; A0A1S3AR63; -.
DR   STRING; 9365.ENSEEUP00000011446; -.
DR   GeneID; 103128603; -.
DR   CTD; 3249; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   InParanoid; A0A1S3AR63; -.
DR   OMA; GQTVPCC; -.
DR   OrthoDB; 4629979at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0070008; F:serine-type exopeptidase activity; IEA:InterPro.
DR   GO; GO:0034769; P:basement membrane disassembly; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0043923; P:positive regulation by host of viral transcription; IEA:Ensembl.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR   GO; GO:2000347; P:positive regulation of hepatocyte proliferation; IEA:Ensembl.
DR   GO; GO:0010756; P:positive regulation of plasminogen activation; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR015352; Hepsin-SRCR_dom.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR   PANTHER; PTHR24252:SF7; HYALIN; 1.
DR   Pfam; PF09272; Hepsin-SRCR; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00202; SR; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF56487; SRCR-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034,
KW   ECO:0000313|RefSeq:XP_007539549.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Serine protease {ECO:0000256|RuleBase:RU363034}.
FT   DOMAIN          163..405
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   417 AA;  45278 MW;  FC2229CAED5DB7C5 CRC64;
     MAEKEGGQKV PFCSRAKLAI LTAGTLLLLT GIGAASWAIV TLLFKNDQEP LYPVQVSPRD
     SRLTVFDEME GTWRLLCSSR SNARVAGLGC EEMGFLRALA HSELDVRTAG ANGTSGFFCV
     DEGRLPHARR LLEVISVCDC PRGRFLTTIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL
     RYDGAHLCGG SLLSGDWVLT AAHCFPERNR ILSRWRVFAG AVAQASPQGL QLGVQAVVYH
     GGYLPFRDPN SEENSNDIAL VHLTSPLPLT EYIQPVCLPA AGQALVDGKL CTVTGWGNTQ
     YYGQQAGVLQ EARVPIISND ICNGPDFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE
     DSISRTSRWR LCGIVSWGTG CALAQKPGVY TKVGDFREWI FQAIKTHSEA SGMVTQL
//