ID A0A1S3ARE3_ERIEU Unreviewed; 627 AA.
AC A0A1S3ARE3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC103128342 {ECO:0000313|RefSeq:XP_007539250.2};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007539250.2};
RN [1] {ECO:0000313|RefSeq:XP_007539250.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007539250.2; XM_007539188.2.
DR AlphaFoldDB; A0A1S3ARE3; -.
DR CTD; 55561; -.
DR eggNOG; KOG0612; Eukaryota.
DR InParanoid; A0A1S3ARE3; -.
DR OrthoDB; 988261at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01243; PH_MRCK; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR PANTHER; PTHR22988:SF22; SERINE_THREONINE-PROTEIN KINASE MRCK GAMMA; 1.
DR Pfam; PF00780; CNH; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_007539250.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 36..155
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 181..455
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT DOMAIN 526..539
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT REGION 533..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_007539250.2"
FT NON_TER 627
FT /evidence="ECO:0000313|RefSeq:XP_007539250.2"
SQ SEQUENCE 627 AA; 68011 MW; 5223286E4BD03866 CRC64;
CGYFCHSTCA PLAPPCPVPP DLLRTALGVH PETGTGTAYE GFLSVPRPSG VRRGWQRVYA
ALSDSRLLLF DAPEARASPA SGALLQVLDL RDPQFSASPV LASDVIHAQP RDLPRIFRVT
ASQLAVPPAT CTVLLLADSE AERERWLQVL GELQRLLQDA RPRPRPVYAL KEAYDNGLPL
LSHTLCAAIL DQERLALGTE EGLFVIHLHT NDIFQVGECR QVQRLAVSAG AGLLVALCGR
GPSVRLFLLA ELESGEAAGA KIAESRGCQA LVAGRILQAR TPVLCVAVKR QVLCYQLGPG
PGPWHHRIRE LQAPAPVQSL GLLGDRLCVG AAGAFALYPL LNEAAPLALG AALVPEELPP
TRGGLGEALG AVELSLSEFL LLFAAVGVYV DGAGRRSRAH ELLWPAVPTG WGYSAPYLTV
FSDNALDVFD VRRAEWVQTV PLKKVRPLNP EGSLFLYGTE KVRLTYLRNR LAEKDEFDIP
DLTDNSRRQL FRTKSKRRFF FRVADEQRLQ QRREMLKDPF VRSKLISQPT NFNHLVHVGP
TDGKPGARAL SPAPGEKGRG GRTSGQQRPH SFSEASRRTV SVSSEGLGGD ANSTVKRKPW
TSLSSESVSC PQGSLSPATS LAQVSRW
//
