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Database: UniProt
Entry: A0A1S3ARP1_ERIEU
LinkDB: A0A1S3ARP1_ERIEU
Original site: A0A1S3ARP1_ERIEU 
ID   A0A1S3ARP1_ERIEU        Unreviewed;       391 AA.
AC   A0A1S3ARP1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-OCT-2019, entry version 17.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 1 isoform X1 {ECO:0000313|RefSeq:XP_007539550.2};
GN   Name=KCNJ1 {ECO:0000313|RefSeq:XP_007539550.2};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae;
OC   Erinaceinae; Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007539550.2};
RN   [1] {ECO:0000313|RefSeq:XP_007539550.2}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_007539550.2; XM_007539488.2.
DR   STRING; 9365.XP_007539550.1; -.
DR   Ensembl; ENSEEUT00000015639; ENSEEUP00000014277; ENSEEUG00000015639.
DR   GeneID; 103128600; -.
DR   CTD; 3758; -.
DR   OMA; LWYWIAK; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000079721; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003268; K_chnl_inward-rec_Kir1.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF6; PTHR11767:SF6; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000079721};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_007539550.2};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     83    105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       43    184       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      192    363       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        171    171       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   391 AA;  44372 MW;  5C209D9AD548349E CRC64;
     MAAQAGSLLK ALIGALTERM FKHLRRWLVT HILGHSRQRA RLVSKDGRCN IEFGNVDAQS
     RFIFFVDIWT TVLDLKWRYK MTIFITAFLG SWFLFGLLWY AVAYIHKDLP EFHPSINHTP
     CVENINGLTS AFLFSLETQV TIGYGFRCVT EQCGTAIFLL IFQSILGVII NSFMCGAILA
     KISRSKKCAK TITFSKNAVI SKRGGKLCLL IRVANLRKSL LIGSHIYGKL LKTTVTPEGE
     TIILDQTNIN FVVDAGNENL FFISPLTIYH VIDHNSPFFH MAAETLPQQD FELVVFLDGT
     VESTSATCQV RTSYVPEEVL WGYRFAPIVS KTKEGKYRVD FHNFSKTVEV ETPHCAMCLY
     NEKDARARMK RGYDNPNFIL SEVNETDDTK M
//
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