ID A0A1S3AS29_ERIEU Unreviewed; 328 AA.
AC A0A1S3AS29;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Free fatty acid receptor 2-like {ECO:0000313|RefSeq:XP_007539559.1};
GN Name=LOC103128611 {ECO:0000313|RefSeq:XP_007539559.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007539559.1};
RN [1] {ECO:0000313|RefSeq:XP_007539559.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_007539559.1; XM_007539497.2.
DR AlphaFoldDB; A0A1S3AS29; -.
DR STRING; 9365.ENSEEUP00000006184; -.
DR GeneID; 103128611; -.
DR CTD; 2867; -.
DR eggNOG; ENOG502QQGM; Eukaryota.
DR InParanoid; A0A1S3AS29; -.
DR OrthoDB; 2899073at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15170; 7tmA_FFAR2_FFAR3; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR013312; GPR40-rel_orph.
DR PANTHER; PTHR45822:SF5; FREE FATTY ACID RECEPTOR 2; 1.
DR PANTHER; PTHR45822; FREE FATTY ACID RECEPTOR 2-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01904; GPR40FAMILY.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_007539559.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..271
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 297..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 36806 MW; 847677EFC6AAC5F1 CRC64;
MPSWENIVTL VAYILIFLTG FPANLLALRA FVGRVRQPQP APIHILLLSL TLADLLLLLL
LPFKMIEAAN DSVWYLPEIV CAMTGFGFYS SIYCSTWLLA GISIERYLGV AFPVQYKLSR
KPVYGIIAAV VAWVMSFGHC TIVIIVQYLD SPQNTTKSEI TCYENFTEFQ LSVVLPVRLE
LCLVLFFIPM FVTIFCYWRF VWIMLTQPHV GAQRRRRAVG LAVVTLLNFL VCFGPYNVSH
LVGFYTKKSP KWRAQAVVFS SLNASLDPLL FYFSSSAVRR AFGKGLQILR HQGSSLLGRR
GKETGDLGNM DRGMSQAEGA PSSDFTTD
//
