ID A0A1S3B4L6_CUCME Unreviewed; 920 AA.
AC A0A1S3B4L6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Katanin p80 WD40 repeat-containing subunit B1 homolog {ECO:0000256|HAMAP-Rule:MF_03022};
GN Name=LOC103486088 {ECO:0000313|RefSeq:XP_008442151.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008442151.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008442151.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May participate in a complex which severs microtubules in an
CC ATP-dependent manner. Microtubule severing may promote rapid
CC reorganization of cellular microtubule arrays. {ECO:0000256|HAMAP-
CC Rule:MF_03022}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000256|HAMAP-
CC Rule:MF_03022}.
CC -!- SIMILARITY: Belongs to the WD repeat KATNB1 family. {ECO:0000256|HAMAP-
CC Rule:MF_03022}.
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DR RefSeq; XP_008442151.1; XM_008443929.2.
DR AlphaFoldDB; A0A1S3B4L6; -.
DR GeneID; 103486088; -.
DR OrthoDB; 1330549at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0008352; C:katanin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR HAMAP; MF_03022; Katanin_p80_B1; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR028021; Katanin_C-terminal.
DR InterPro; IPR026962; KTNB1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19845; KATANIN P80 SUBUNIT; 1.
DR PANTHER; PTHR19845:SF15; KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1 HOMOLOG KTN80.2; 1.
DR Pfam; PF13925; Katanin_con80; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03022};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|HAMAP-
KW Rule:MF_03022}; Microtubule {ECO:0000256|HAMAP-Rule:MF_03022};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 11..53
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 54..95
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 96..137
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 138..179
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 180..221
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 759..917
FT /note="Katanin p80 subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13925"
FT REGION 306..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 101554 MW; F2871E133915A6EF CRC64;
MAKRGYKLQE FAAHSGNVNC LSIGKKACRL FITGGDDYKV NLWAIGKPNS LMSLCGHTNP
VESVAFDSAE VLVLAGASSG AIKLWDLEEA KMVRTLSGHR SNCTAVEFHP FGEFFASGSR
DTNLKIWDIR KKGCIHTYKG HTQGISTIKF TPDGRWVVSG GFDSAVKVWD LTAGKLMHDF
KFHEGPIRSI DFHPLEFLLA TGSADKTVKF WDLETFELIG STRPEAAGVR AITFHPDGRT
LFSGLDESLK VYSWEPVICH DSVDMGWSTL GDLCIHAGKL LSCSSYRNSV GVWVADVALI
EPYGASSVSG QKEPKEQKPG SAFKNSLGSK STGSDLMTSN LQSLSPDYET KEIKNIYIDT
TGGKPVSPQK AESLSSPKIV FALDSKEISY DASKKQNPAS RVEVKSNELS KDKPPVVPCD
SPEVKDSPSS VRESITFSKT RRGMLLRPAH IRKPSNSKID LEKLSVSVDS SRKTDLERLP
VVDSVNVCNT TNDLNKAPVQ NLKTSVVSEV IHIDSCGTNS DIISIEKFEK GPSVSVDTTS
EQETRNKSVE NSKGANSVKF VNGVVPGRTR TLVERFERRE KTNDVQTTIS PSNVLEPEKT
REQTNSLEVQ VVTPQILETE KTREQTNDYR VQAVTMPSHV SETETRSEQT SNYEVQAVAI
PSLVSETEKA REQTNNYEVR AMVIPRTPET KRMGINYEAK SRSNYEAKTR NNYEAKSTLI
SSRVPETDKT DSSQKGEPQI SGRDSTSAND RDVIEDLMQS HDIFLSTLRS RVTKLQVVRH
FWERNDMKGA INAMTKLPDH SVQADVISVL IDKMDVLTLD LFSCLLPVLV GLLDSKIERH
ASLSMEILVK LVAVFGHVIS SAVSAPPVVG VDLHAEQRVQ CCKQCFTQLQ KIQKVIPSFV
RRGGSLARSA QELNLVLQQC
//
