ID   A0A1S3B4P6_CUCME        Unreviewed;       545 AA.
AC   A0A1S3B4P6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Probable apyrase 6 {ECO:0000313|RefSeq:XP_008441708.1};
GN   Name=LOC103485786 {ECO:0000313|RefSeq:XP_008441708.1};
GN   Synonyms=103485786 {ECO:0000313|EnsemblPlants:MELO3C008546.2.1};
OS   Cucumis melo (Muskmelon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX   NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008441708.1};
RN   [1] {ECO:0000313|Proteomes:UP000089565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX   PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA   Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA   Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA   Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA   Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA   Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA   Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA   Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT   "The genome of melon (Cucumis melo L.).";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN   [2] {ECO:0000313|EnsemblPlants:MELO3C008546.2.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [3] {ECO:0000313|RefSeq:XP_008441708.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_008441708.1; XM_008443486.2.
DR   EnsemblPlants; MELO3C008546.2.1; MELO3C008546.2.1; MELO3C008546.2.
DR   GeneID; 103485786; -.
DR   Gramene; MELO3C008546.2.1; MELO3C008546.2.1; MELO3C008546.2.
DR   KEGG; cmo:103485786; -.
DR   eggNOG; KOG1386; Eukaryota.
DR   InParanoid; A0A1S3B4P6; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000089565; Unplaced.
DR   Proteomes; UP000596662; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF3; APYRASE 6-RELATED; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        45..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        502..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        202
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         232..236
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   545 AA;  60832 MW;  5BC3314DDEE980F5 CRC64;
     MRRLNARKRD GSKITNMDPT KLHLRPSSRP NLFARANSKN SKSRLWVSLA ALLAFAFFLF
     SLFVFARNLR SSLKRRYGIV IDGGSTGSRI HVFGYRVEAG YGVFDFGEEG LASMKVNPGL
     SAYARDPDGA GKSLVELLEY AKSRVPRDQW GVTEIRLMAT AGLRLLELDV QNRILESCRH
     LLRSSGFKFQ DEWASVITGS DEGTYAWVAA NFALGTLGGD PLETTGIIEL GGASAQVTFV
     SSEPIPSEFL RTVKFGNMTY SLYSHSFLHF GQNAAHDSLR EGLIKGEFNS GARTLQNGLS
     VDPCTPNGYS HISESEALSP GYMVERNRYL STFHSKGNFS ECRSVALMLL QKGKEKCTNR
     NCSVGSIYTP KLRGKFLATE NFFYTSKFFG LGSRAFLSDL MVAGEEFCGE DWLELKKRYK
     LLDEEDLLRY CFSSAYIVAL LHDSLGIGLD DTSITAATHV QNIPLDWAMG AFILQSTAAI
     EAEPEQWDWI VAIFGYELPT KFSLIVVSIL LLFIAWSVSK WRKPQLKTIY DLEKGRYIVT
     RVTKS
//