GenomeNet

Database: UniProt
Entry: A0A1S3B9B7_CUCME
LinkDB: A0A1S3B9B7_CUCME
Original site: A0A1S3B9B7_CUCME 
ID   A0A1S3B9B7_CUCME        Unreviewed;      1393 AA.
AC   A0A1S3B9B7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 18.
DE   SubName: Full=endoribonuclease Dicer homolog 2 isoform X1 {ECO:0000313|RefSeq:XP_008443670.1, ECO:0000313|RefSeq:XP_008443671.1, ECO:0000313|RefSeq:XP_008443672.1};
GN   Name=LOC103487216 {ECO:0000313|RefSeq:XP_008443670.1,
GN   ECO:0000313|RefSeq:XP_008443671.1, ECO:0000313|RefSeq:XP_008443672.1};
OS   Cucumis melo (Muskmelon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae;
OC   Benincaseae; Cucumis.
OX   NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008443671.1};
RN   [1] {ECO:0000313|Proteomes:UP000089565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX   PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA   Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA   Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA   Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA   Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA   Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA   Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B.,
RA   Gabaldon T., Roma G., Guigo R., Casacuberta J.M., Arus P.,
RA   Puigdomenech P.;
RT   "The genome of melon (Cucumis melo L.).";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN   [2] {ECO:0000313|RefSeq:XP_008443670.1, ECO:0000313|RefSeq:XP_008443671.1, ECO:0000313|RefSeq:XP_008443672.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_008443670.1; XM_008445448.1.
DR   RefSeq; XP_008443671.1; XM_008445449.1.
DR   RefSeq; XP_008443672.1; XM_008445450.1.
DR   STRING; 3656.XP_008443670.1; -.
DR   GeneID; 103487216; -.
DR   KEGG; cmo:103487216; -.
DR   KO; K11592; -.
DR   OrthoDB; 1337630at2759; -.
DR   Proteomes; UP000089565; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 2.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000089565};
KW   Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}.
FT   DOMAIN       27    206       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      379    538       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      558    640       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN      829    928       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN      958   1110       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1146   1293       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1319   1386       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   COILED      248    268       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1393 AA;  158180 MW;  FDA1E0D1AE8B5EB3 CRC64;
     MASNMETENE QLVADPLSFA RSYQLEGLEK ALKQNTIVFL ETGSGKTLIA IMLLRSFAHQ
     LRKPSPFVAV FLVPQVVLVT QQAEALKMHT DLSVGLYYGD MGIDFWDGAI WKREIEKHEV
     LVMTPAILLN GLRHSFFHIS MIKVLVLDEC HHARGKHPYA CIMTEFYHQQ LSLGKSDLPR
     IFGMTASPIK SKGGNSELNY WQYIQELESL LNSKVYTVSS ESELANFVPV STPKFKFYIR
     KDIPYALYEQ LANALKVLKS KHEQSLENSD LNPSKVEPTR KRISKAFLAL MYCLDELGLW
     LTWKAAETLS WMEDDFSPWE TLDIFGEAIV KSFCSDALKL LANPLKSGCS YGSIGDNVEA
     DMAAGLMTPK VVCLIASLLE YRSIEDIRCI VFVERIVSAV ALQTLLSLLL PKHTCWKTKY
     IAGSTSGLQT QSKKKQNEIV EEFRCGKVNI IVATSILEEG LDVQSCNLVI RFDPSSTVCS
     FIQSRGRARM KNSDYILMVK SGDSATLSRL QRYLASGEIM RNESLCHASL PCLPFRSAYD
     EESYFVESTG AIVTLSSSVG LIYFYCSRLP SDCYFKPTPR WDKETCTLYL PKSSPLQTFS
     SKDDAKYSKQ SACLEACKQL HKYGALTDNL VPQMVAEESV AQEIGNKPLD DEQPIYVPPE
     FVHCCPHNSS VVYHCYLIEL KQNFHYDISA HNIVLAMRTE LEFEVQSMCH DLDVDRGSFD
     VNFKYVGIIK LSPEQVLLSR QFQRTIFRAL LNHTWTNKLS ENNEIYLGDG PKVDYLLLPS
     TGVELISWEI VLSVLFSSRE YCVHRGISSS KGLAYDVQTK SGLVCICRLQ NSLVYTPHNG
     HVYCITSVLS ELNGNSSLKI RKNEMMAYKE YYKVRHGIDL YFEKQPLLRG KKIFPVHNYL
     KRFRKHKEEG ESRNSLVELP PELCSIIMSP ISVNTLYSYS FLPSIMHRLE SMLIASNLKK
     LNTDHCMQND IPTTKVLEAI TTKNCQEKFH LESLETLGDS FLKYATGQHL FRTFQNDHEG
     LLSLKKDRIV SNAALCRLGC EHKISGFVRD EAFDPQKWDI PGDTHEVSQL REVVLSSGRK
     VYVRRKRKIK GKRIADVVEA LIGAYLSTGG ERAAIQFLNR IGIELNFDFV PYERPFRVDA
     HKLINVGHVE SLLKYTFNDR SLLLEALTHG SYMLPEIPRC YQRLEFLGDS VLDYAITVHL
     YNKYPGMTPE LLTDMRSASV NNDCYSRTAL KAQLHKSILH CSHDLHKHIS STLHNFEMLS
     SEATYGWESE ISFPKVLGDV IESLAGAIYV DSGYDKEKVF GCIRPLLEPL VSPETLKKHP
     RRELNELCQK EKYNLKKTVT SRVNGRSHVT VEVEVNGRIF KHTAISLDRE TGKKVASKEV
     LKSLKESYPM VHK
//
DBGET integrated database retrieval system