ID A0A1S3BAM2_CUCME Unreviewed; 389 AA.
AC A0A1S3BAM2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Type III polyketide synthase A {ECO:0000313|RefSeq:XP_008444217.1};
GN Name=LOC103487618 {ECO:0000313|RefSeq:XP_008444217.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008444217.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008444217.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
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DR RefSeq; XP_008444217.1; XM_008445995.2.
DR AlphaFoldDB; A0A1S3BAM2; -.
DR GeneID; 103487618; -.
DR KEGG; cmo:103487618; -.
DR eggNOG; ENOG502QSSY; Eukaryota.
DR InParanoid; A0A1S3BAM2; -.
DR OrthoDB; 883077at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003633};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transferase {ECO:0000256|RuleBase:RU003633}.
FT DOMAIN 18..236
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 246..389
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 172
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 389 AA; 43128 MW; 954E1EC340C9833C CRC64;
MSKMSCESSA MLDHARARRV PTPGTATILA LGKAFPSQLV PQECLVEGYI RDTKCIDTTI
KEKLERLCKT TTVRTRYTVM CKEILDKYPE LVTEGSPTIR QRLEIANSAV VEMATEASKA
CIKEWGRSVE DITHIVYVSS SEIRLPGGDL YIANQLGLKN DVGRVMLYFL GCYGGVTGLR
VAKDIAENNP GSRVLLTTSE TTILGFRPPN NARPYDLVGA ALFGDGAAAV IIGADPMLGQ
ESPFMELNYA IQQFLPDTQN VINGKLSEEG ISFKLGRDLP QRIDDNIEGF CRKLMKKRNL
MNFNDLFWAV HPGGPAILNK LENTLRLKSE KLECSRKALM DYGNVSSNTI FYVIENMREN
LKREDGEEWG LALAFGPGIT FEGILIRSL
//
