ID A0A1S3BCB6_CUCME Unreviewed; 919 AA.
AC A0A1S3BCB6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Glutamate receptor {ECO:0000256|PIRNR:PIRNR037090};
GN Name=LOC103488369 {ECO:0000313|RefSeq:XP_008445295.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008445295.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008445295.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. {ECO:0000256|PIRNR:PIRNR037090}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685, ECO:0000256|PIRNR:PIRNR037090}.
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DR RefSeq; XP_008445295.1; XM_008447073.2.
DR AlphaFoldDB; A0A1S3BCB6; -.
DR GeneID; 103488369; -.
DR KEGG; cmo:103488369; -.
DR eggNOG; KOG1052; Eukaryota.
DR InParanoid; A0A1S3BCB6; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd13686; GluR_Plant; 1.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF586; RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRNR:PIRNR037090};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037090};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037090};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037090}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..919
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010317170"
FT TRANSMEM 591..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 461..811
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DISULFID 759..815
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 919 AA; 103622 MW; 2D9AE08416211FCD CRC64;
MRRRKGMKSG FWVLLMMLLL AAAMVAAKEG EEEEEKAAVA VKVKVGVVFD WDDYGKVDFS
CISMALSDFY ASRSYYKTRV VLKPMDSNGT VVDAAAAALE LIKKEEVQAI LGPTSSMQAN
FMIDIGDKAQ VPIISFSATR PSLTSHRSSF FFRVAQDDSS QVKAIGAIVK TFKWRKVVPI
YVDNEFGDGI IPYLIDALQE VNAHVPYQSI ISPDVTDDHL TSELYKLMTM QTRVFVVHML
SDLASRIFTK AKQIGMMKKG YVWIITDGVT NMLESIKPST FESMQGVIGI KTYVPRTEKL
ESFERDWRKR FLGSYPKMEE VPELDVFALW AYDAAWALAI AVEKAGTDNL RYSPTNFTSL
NYLYNLGLNQ NGGKLRDAFS KVKFKGLSGD FSVKHGQLDW EIFEIVNVIG NGRRNVGFWS
PESGLRTELE RGRNGLRTII WGGGDSGFPP KGWEIPTNEK KLRVVVPVKD GFWDFVSVVR
DPVTNETKVS GYCIDVFKAV IEALPYAIAY ELIPYHKSAA EPGGTYNDLV DQIYLGEFDA
LVGDLTIRAN RSRYIDYTLP FAESGVSMVV PIMSTKNTNA WVFIKPLTGH LWSLTGGFFL
VMALVVWILE HRVNEEFRGS PADQVFTSLW YSFSTMVFAH REITLNNWTR FVMIVWLFVV
LIITQSYTAS LASYLTVQEF KPAVTDINQL QKNGEKIGHK VGSFIHEILK SLKFEEYQLK
TYRTAEEMHD LLSKGSANGG ISAAMDENPY IKLFLAKYCS RYTTTEPTFK ADGFGFGFPK
GSPLVPDISR AILEVTESDR MREIENAWFK KLGECSISDA SKLSSTRLSI DSFWALFVIV
TCVSAVSVIC YIIKFLYDQK GVWSKEIRST TGEKLRELVK TFMDRDAGTH PLRRRVFING
APIHPQPLVI RDNDHPRAD
//
