ID A0A1S3BF04_CUCME Unreviewed; 1221 AA.
AC A0A1S3BF04;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Cysteine-rich receptor-like protein kinase 10 {ECO:0000313|RefSeq:XP_008446411.2};
GN Name=LOC103489161 {ECO:0000313|RefSeq:XP_008446411.2};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008446411.2};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008446411.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR RefSeq; XP_008446411.2; XM_008448189.2.
DR AlphaFoldDB; A0A1S3BF04; -.
DR eggNOG; ENOG502QWDY; Eukaryota.
DR InParanoid; A0A1S3BF04; -.
DR OrthoDB; 3900892at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 2.
DR Gene3D; 3.30.430.20; Gnk2 domain, C-X8-C-X2-C motif; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR002902; GNK2.
DR InterPro; IPR038408; GNK2_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR27002:SF427; OS07G0628700 PROTEIN; 1.
DR PANTHER; PTHR27002; RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF01657; Stress-antifung; 2.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51473; GNK2; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_008446411.2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000313|RefSeq:XP_008446411.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 835..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 188..466
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 580..685
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 691..798
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 898..1174
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1196..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..82
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..826
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 216
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 926
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1221 AA; 136755 MW; A57CAD52ED9A1246 CRC64;
MAMEAPTNIS LRRRSLTAPV SPSDQIFRYV VVNASAVDLP PPPPPSPPPP PPSSPPPPPS
SPPPNVPPPP FPDAPPPAQS WTELNPSPST PSPLSSLSMP LPPATSPDLS PLPGESRYSS
LPMIILVLIA TSLFIPLLVR GYKCFIRRGA KKKHTTLKKE DSTFVTEFTS IESLQYDFNT
IDAATSNFSA DNKLGEGGFG AVYKGMLDNG QEIAVKRLSR RSLQGSEEFK NEVMVVSKLQ
HRNLVRLLGF CLEGEEKILI YEYIPNKSLD YFLFDSKRRQ ELDWLSRYKI INGIAREILY
LHEDSRLRII HRDLKASNVL LDDNMHPKIS DFGIARIIQV ADQNNQANIT NRIVGTYGYM
SPEYAMYGNF STKSDVYSFG VLILEIISGK KNSTFYLSEL AEDILTYAWK LWKEEMALEL
SDPSLETRYS KDEVLRCIHI GLLCVQDDPS RRPSMASIVL MLNTYSVPLP LPEEPTIFMH
NTDNAIVINS DQLATNLFIS STNEISITEL HQVAVAKKIV YPINSAKSFF SVHIILTICS
KTLSRPTFFK LQYNSFTMLN LLTFIFLLNL LTHGNAQNEA SYPYRRCLTG NFTQNSTYQA
NLNLLFSTLS TNGPPTNRFF NTSVGRSPND TVYGLFQCRG DVTNATCRTF LATATRDAER
LYCPLAKGAV IWYDEIIFRY SDQPFFSIIT STPNLRLLNL VNIDGDKARF NQLVMSTLRA
TAALAASSMD ELFATQMANF TQDRNIYTLA QCTGDLSNTD CGECLRQATN EIPNCCTDKQ
GGRVLLPSCI VRYEVYSFYE TSIPPPATPT PISTIPSRPL LPSSPPPGER RSSTVLIVAI
VAPITVSILL FVMGCCFLRQ RAKKRDSAVK EDSVVDEMTT SDSLQFDFKT IEAATNKFSE
ENRLGEGGFG AVFKGRLDNG QEIAVKRLSR GSLQGSEEFK NEVMLVAKLQ HRNLVRLLGF
CLEGEEKILI YEFIPNKSLD FFLFDQEGQK QLDWLKRYKI INGIARGILY LHEDSRLRII
HRDLKASNIL LDGDMNAKIS DFGMARIIQM DQSQGNYTSR IVGTYGYMSP EYAMHGNFSM
KSDIYSFGVL VLEIISGRKN NTFYLSDLAE DILTYAWALW KDGIPLELLD PMLKDNYSRN
EVLRCIHIAL LCVQEDPNSR PSMASIVLML NSYSVTLPIP KEPALFVRSK DNGNTIGSDH
SSNKSTKCSV NETSLSELHP R
//
