ID A0A1S3BJF8_CUCME Unreviewed; 2721 AA.
AC A0A1S3BJF8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC103490258 {ECO:0000313|RefSeq:XP_008447915.1};
GN Synonyms=103490258 {ECO:0000313|EnsemblPlants:MELO3C013324.2.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008447915.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|EnsemblPlants:MELO3C013324.2.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_008447915.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR RefSeq; XP_008447915.1; XM_008449693.2.
DR EnsemblPlants; MELO3C013324.2.1; MELO3C013324.2.1; MELO3C013324.2.
DR GeneID; 103490258; -.
DR Gramene; MELO3C013324.2.1; MELO3C013324.2.1; MELO3C013324.2.
DR KEGG; cmo:103490258; -.
DR eggNOG; KOG0890; Eukaryota.
DR InParanoid; A0A1S3BJF8; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR Proteomes; UP000596662; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_008447915.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1654..2267
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2378..2691
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2689..2721
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1413..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2116..2136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1413..1427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2721 AA; 305364 MW; BCA6FA6B8396060E CRC64;
MANLSTLVHE LRERIAASSS TPNRADDFGL EVRFRAFLPN LLHDHVVPSS SVNEREVVAV
LKLISITARN FPGVFYHGKA SAVLPVIARI LPFFAETTIQ AQHGVIFETV GSLLSLLRTG
ARDAYRQFFL DAMSVVEDIL YTASLGTDTS SFVESTSINL NCFCESLKGI FEDPDHLVDL
PEVNRPTNGS GILINLTGKK RWRPFATWII KLLGRCLAEG TVYVEGLISM SDVSAACSLL
CYGDADLQMA CFDFARIVGL VIDDIVPYQP LIQSISTILS EDKQGLPVFR NIPYDTSIGG
CLNVLYSNCC DDVVKLTAAD MVGIFSQSLW RTKSMELKVS LCNAYMRIAK ICPSHIWRPE
ILVDMLSFPE PCFALIDCFK AVLSILGPDY VGGSLPGMGS SELSNKSIET SRIGEKRPFE
DLDIVKKKRP KMDGEIVSSE ADIMVECKKP HVKICETEET YANNLHNLLV SFVGCLKASS
IRADALRPEV SLTALSMLCI AFCRYPETRL SMVIFQEMIS WIPWIYEQAK KGSSISIDIS
IFLEGIHNIL LLPNHISSCL FSLLSGSNGE CAETMSVILK VPWTHSITST ESHKPWKTRC
ISVQVSSKIT SITKDETDLE VLDLSLVDED DEVRTEAAIS IPVIALWTGF DRLTPLFRRL
EILKEEMHEK VKKIIPVSLG FLSCLYGSCH SVSRCKLFLN TNSDRCCQTV DYVLQGFWCS
KCDQTVVHDH ELYTNIIEQS DCYPKMNLDS DFVHLVSMFF KLLFDESSEE VQLSCVGTLR
RILVHGRRGV LHQMKTNWLK CVEFLLLNRK KSIREAFCLQ ISSFLEDHIT SCFFSEEDIS
NKRKEVMFLD FIKNAMVSTA DPQILDTILE SVAELMNAVD IHSDFFSLSL LLLVDHLDNP
HITVRLSASR AIHRACCFHF NGNFDMIFSK VIHLRNELFD HVSSRLVNHP KIVQEFAEAV
LGVETEVFVK KMIPVVLPKL IVSHQNNDQA VESLYELAKC VDTDMVTLIV NWLPKVLAFV
LYQANGKELC SALEFYHAQT GSTQEEIFAA ALPALLDELV CFVDGGNSDE VSKRLARVPE
MILQVARVLT GGDDLPGFLR NHFVGLLNSL DRKMLHAEDV CLQKQALQRI EMLIKLMGSH
LSTYVPKLMV LLMHAIGKEE LQSEGLIVLN SFIQQLAMVS PSSIKYVISQ VFAALVPFLE
RDETSTHLDM VVKILEELVL KNKSILKVHI REFPPLPCIS ALTEVNRAIN ETRGSMTLKD
QLRNVVDGLN HENLKVRYMV ACELRKLLNM RSKEVTTLIS AEADLDMDVL SLLISSLLRG
CAEESRTAVG QRLKLICADC IGALGAVDPA KVKSFSCERF KIECSDDDLI FELIHKHLAR
AFGAAPDTII QDSAALAIQE LLKIAGCKAS LDDNTAPSAS PSLKDKETSK TVTSDSSDDG
HAMSIRGQRL WGRFSDYVKE IIAPCLTSRF QLPNVVDSAF ASSIYRPGMS FRRWIYFWIK
KLTAHATGSR AGIFHACRGI VRHDMQTAVY LLPYLVLSAV CHGTEEARHG ITEEILSVLN
AAAAENGVAL IHGNTGGQSD VCIQAVFTLL DNLGQWVDDV ERGLSLSQSG QSSSSKHLVA
KSRESSSIVH VDQEQLLVQC RYVSQLLDAI PKTTLARASL SCQAYARSLM YFESYVRGKS
GSFNPAAERS GIFEDEDISY LMEIYSCLDE PDGLSGLACL RKSLRLQDQL LINKKAGNWA
EVLTFCEQAL HMEPDSVQRH SDVLNCLLNM CHLQAMVTHV DGLITRIPQY KKTWCMQGVQ
AAWRLGRWDL MDEYLKGADE EGLLCSSSES NASFDMDVAK ILQAMMKKNQ FSVSEKIALS
KQSLIAPLAA AGMDSYARAY PFVVKLHLLK ELEDFHNLLF NDSFLEKSFH VDDQEFSEMI
QNWENRLKFT QSSLWAREPL LSFRRLVFGA SSLGAQVGNC WLQYAKLCRS AGHYETAKRA
ILEAQASRAP NVHMEKAKLL WSTRRSDGAI SELQQSLLNM PVEVIGSAAM SSITSLSLVP
MNPAPLICDT QTLNENRDIA KTLLLYSRWI HCTGQKQKED VINLYSRVKE LQPKWEKGYF
FMARYCDELL EDARKRQEDS LEQGPRKVSS SSTAIGPSNL NNEKPWWSYV PDVLLFYAKG
LHRGHKNLFQ ALPRLLTLWF DFGSIYQRVG SSSNKELKSV HGKVLSIMRG CLKDLPAYQW
LAVLPQLVSR ICHQNEETVR LVKYIIASVV RQYPQQALWI MAAVSKSTVP SRREAAMEII
HSAKKDFSQG NGGNNLFLQF ASLIDHLIKL CFHPGQQRAR NINISMEFST LKRMMPLEII
MPIQQSLVVN LPTYDANLTD SPSSDIFSGT ELPTISGIAD EAEILSSLQR PKKIILLGSD
GIERPFLCKP KDDLRKDARM MEFTAMINRL LSKYSESRRR KLYIRTFAVI PLTEDCGMVE
WVPHTRGLRH ILQDIYITCG KFDRQKTNPQ VKRIYDQCQG KIPESEMLKT KILPLFPPVF
HRWFLNTFSE PAAWFRARIA YAHTTAVWSM VGHIVGLGDR HGENILFDST TGDCVHVDFS
CLFDKGLQLE KPELVPFRLT QNMIDGLGIT GYEGIFLRVC EITLSVLRSH RDTLMSILET
FIHDPLVEWT KSHKSSGVEV QNPHAQLAIS NIEARLRGVV VGVGAAPSLP LAVEGQARRL
IAEAVAHKNL GKMYIWWMPW F
//
