ID A0A1S3BRH8_CUCME Unreviewed; 732 AA.
AC A0A1S3BRH8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=LOC103492738 {ECO:0000313|RefSeq:XP_008451444.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008451444.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008451444.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008451444.1; XM_008453222.2.
DR AlphaFoldDB; A0A1S3BRH8; -.
DR GeneID; 103492738; -.
DR KEGG; cmo:103492738; -.
DR eggNOG; KOG0925; Eukaryota.
DR InParanoid; A0A1S3BRH8; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|RefSeq:XP_008451444.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_008451444.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565}.
FT DOMAIN 78..247
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 272..452
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 732 AA; 83281 MW; C4CAE22B5398C46E CRC64;
MGAERKRKVS LFDVVDETSV SAKLNKVNGG VAPLNNGGGN AGNSLINRWT GRQFSQRYYE
ILEKRKTLPV WHQKEEFFQA LKSSQTLILV GETGSGKTTQ IPQFVLEAVD LDSPDKRKKM
MVACTQPRRV AAMSVSRRVA EEMDVTIGEE VGYSIRFEDC SSARTVLKYL TDGMLLREAM
TDPLLERYKV IILDEAHERT LATDVLFGLL KEVLKNRPDL KLVVMSATLE AEKFQGYFYG
APLMKVPGRL HPVEIFYTQE PERDYLEAAI RTVVQIHLCE PPGDILVFLT GEEEIEDACR
KINKEIGNLG DQVGPVKVVP LYSTLPPAMQ QKIFEPAPPP VKEDGPAGRK IVVSTNIAET
SLTIDGIVYV IDPGFSKQKV YNPRVRVESL LVSPISKASA HQRSGRAGRT QPGKCFRLYT
EKSFQNDLQP QTYPEILRSN LANTVLTLKK LGIDDLVHFD FMDPPAPETL MRALEVLNYL
GALDDDGNLT KLGEIMSEFP LDPQMSKMLV VSPEFKCSNE ILSISAMLSV PNCFVRPREA
QKAADEAKAR FGHIDGDHLT LLNVYHAYKQ NNEDQSWCYE NFINHRAMKA ADNVREQLVR
IMSRFNLKLC STDFNSRDYY ANIRKAMLSG YFMQVAHLER TGHYLTVKDN QVVHLHPSNC
LDHKPEWVIY NEYVLTSRNF IRTVTDIRGE WLVDIASHYY DLENFPQCEA KRVLERLYKK
REKDREESRN RK
//
