ID A0A1S3BSG8_CUCME Unreviewed; 759 AA.
AC A0A1S3BSG8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=CSC1-like protein At4g02900 isoform X1 {ECO:0000313|RefSeq:XP_008451392.1, ECO:0000313|RefSeq:XP_016901038.1};
GN Name=LOC103492693 {ECO:0000313|RefSeq:XP_008451392.1,
GN ECO:0000313|RefSeq:XP_016901038.1};
GN Synonyms=103492693 {ECO:0000313|EnsemblPlants:MELO3C015860.2.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008451392.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|EnsemblPlants:MELO3C015860.2.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_008451392.1, ECO:0000313|RefSeq:XP_016901038.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR RefSeq; XP_008451392.1; XM_008453170.2.
DR RefSeq; XP_016901038.1; XM_017045549.1.
DR EnsemblPlants; MELO3C015860.2.1; MELO3C015860.2.1; MELO3C015860.2.
DR GeneID; 103492693; -.
DR Gramene; MELO3C015860.2.1; MELO3C015860.2.1; MELO3C015860.2.
DR KEGG; cmo:103492693; -.
DR eggNOG; KOG1134; Eukaryota.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR Proteomes; UP000596662; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF96; OS05G0393800 PROTEIN; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..176
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 197..359
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 370..642
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 733..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 87144 MW; 73CDD27F37496BBF CRC64;
MANLQDIGVS ATINLLSALA FLVAFALLRL QPINDRVYFP KWYLKGIRGS PRRSGHVHDV
VNLDFNMYIR FLNWMPAALK MPEPELVEHA GLDSAVFVRI YLLGLKIFVP ITFLAFAVLV
PVNWTGETLE HEKGLAYSDI DKLSLSNIPP ASKRFWAHIV MFYVFSFWTY YILYKEYKII
ASMRLRFLAS QKRRPDQFSV LLRNVPLDPD ESISEHIEHF FCVNHPDRYL THQLVYNANH
LAKLVEKKKG LQNWLVYYEN KYERNPSQRP TTKTGFWGLW GSTVDAIDYY TTEVEKISTE
EDVEREKVLS DPNSLIPAAF VSFKTRWAAA VCAQTQQSSN PTIWLTEWAP EPRDIYWENL
AIPYVKLAIR KLIMAVALFF LTFCFMVPIT FVQSLANIEG IEKVFPFLKP IIEKKVIKSV
IQGFLPGIAL KIFLILLPRI LMTMSQIEGF TSLSALDRRS AEKYHMFILV NVFFGSVITG
TALQQLQKFL NEPSTEFTKT VGDSIPMKAT FFITYIMVDG WAGIAAEILR LVPLIIFHLK
NTFLVKTDQD RDQAMDPGCL DFPVSEPRIQ LYILLGFVYS VVTPILLPFI IVFFSFSYLV
YRHQIINVYN QKYESGAAFW PHVHRRVIIG LILAQLLLMG LFSMREAEKS SLFLVALPIL
TIWVHKFCKG RFESAFVKFP LQDAMVKDTL EKATEPNLDL KAYLKDAYVH PVFKSSSIEQ
TLLIDDEENN TLVPTKRTSH RGSKLPSEDN SETDAYAGC
//
