ID A0A1S3BV25_CUCME Unreviewed; 1293 AA.
AC A0A1S3BV25;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Niemann-Pick C1 protein isoform X1 {ECO:0000313|RefSeq:XP_008452964.1};
GN Name=LOC103493815 {ECO:0000313|RefSeq:XP_008452964.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008452964.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008452964.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008452964.1; XM_008454742.2.
DR GeneID; 103493815; -.
DR KEGG; cmo:103493815; -.
DR eggNOG; KOG1933; Eukaryota.
DR InParanoid; A0A1S3BV25; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 838..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1120..1139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1145..1168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1175..1196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1216..1236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1248..1271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..790
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1293 AA; 141518 MW; 883CFD91DBFC580F CRC64;
MRLRLGFILS IYLLQVLCFV LVYAEMSNTR LQLSTNGTSG EKHSEGYCVM YGICAKRPDG
KALNCPTGAP SVQPDNLLSS KIQSLCPTIT GNVCCTEQQF DTLRSQVMQA IPFLVGCPAC
LRNFLNLFCE LTCSPNQSLF INVTSVLKVN NSLTVDAIDY YVADAFGEGL YESCKDVKFG
TMNTRAMQFI GADAKNFKEW FAFIGKQAGP GLPGSPYAIG FPSTVSVSSG MKHMNASAYS
CGDTSLGCSC GDCPSAPVCS TTATPVFHRK KSCSVRIGSL KVKCVDFTLC ILYFIIASAF
LGWSLFYRKS QKSLSSGTKT MPNIMDGGSL HSATRQKDES LPMQMLEDAP QIRSRIQLSV
VQGYMSNFYR KYGTWVARNP TLVLISSLAI VLLLCLGLLR FKVETRPDKL WVGPGSKASQ
EKEFFDSHLA PFYRIEQIII ATVPDSVHGK PPSILNDNNI KLLFDIQKKI DGIRANYSGT
SISLSDICLK PLDQECATQS VLQYFQMNPE NVDNYGGVDH LEYCFQHYSS ADSCRSAFEA
PLDPSTALGG YSGNNYSEAS AFLITYPVNN AINKEGNESG PAVAWEKAFI QLAKAELLTM
VQSQNLTLSF SSESSIEEEL KRESTADVIT ILISYLVMFA YISLTLGDRP HLSTFYVSSK
VLLGLSGVVL VMLSVLASVG FFSAIGVKST LIIMEVIPFL VLAVGVDNMC ILVHAVKRQS
VELPLEGRIS NALVEVGPSI TLASLSEVLA FAVGSFIPMP ACRVFSMFAA LAVLLDFLLQ
VTAFVALIVF DFLRTEDKRV DCFPCIKSSR YAGSDKGITQ RSPGLLARYM KEIHAPALSI
WMVKIVVISI FVGFTLASIA LCTRIEAGLE QKIVLPKDSY LQGYFNNISE HLRIGPPVYF
VVKNYNYSSE SRQTNQLCSI SQCDSDSLLN EIAKASLIPE SSFIAKPAAS WLDDYLVWIS
PEAFGCCRKF TNGSYCPPDD QPPCCTSSGG GDSCGLNGVC KDCTTCFLHS DLHGGRPSTA
QFKEKLPWFL SALPSADCAK GGHGAYTSSV DLKDYENGVI QASSFRTYHT PLNKQVDYIN
SMRAAQELSS RLSDSLKIEI FPYSVFYMFF EQYLNIWRTA LINLAIAIGA VFIVCLIITC
SLWTSAIILL VLAMIIVDLM GVMAILNIQL NAISVVNLVM SVGIAVEFCV HLTHAFSVSS
GDRNQRMKEA LSTMGASVLS GITLTKLVGV LVLCFSRTEV FVVYYFHVYL ALVLLGFLHG
LVFLPVVLSL FGPPSRCVFV EQQDNRPSTS SRS
//
