ID A0A1S3BV84_CUCME Unreviewed; 478 AA.
AC A0A1S3BV84;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000313|RefSeq:XP_008453018.1};
GN Name=LOC103493848 {ECO:0000313|RefSeq:XP_008453018.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008453018.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008453018.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR RefSeq; XP_008453018.1; XM_008454796.2.
DR AlphaFoldDB; A0A1S3BV84; -.
DR GeneID; 103493848; -.
DR KEGG; cmo:103493848; -.
DR eggNOG; KOG1430; Eukaryota.
DR InParanoid; A0A1S3BV84; -.
DR OrthoDB; 5487986at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028110; TMEM254.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF14934; TMEM254; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..295
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 478 AA; 53375 MW; 83004F15B0F2F64F CRC64;
MHLSANEGIE GNTFAVTGGL GFAGSSLCLD LLRRGALQVR AFDLRSVSPW SDHLKTHGVK
IIQGDVTCKK DVERALRGVD CVFHLAAYGL SGKEMLQVGR IDEVNINGTC HVLDACLEFG
VRRLIYMSTY NVVFGSQEIV NGNEGLPYLP IDDHVDAYGR SKSIAEQLVL KTNGRPLKNR
NGKCLRTCAI RSCAIYGPGE ERHFPRLVSL AKLGLLPFRV GKQSAKTDWI YVDNLVLALI
LASMGLLDDI PGKGRDPVAA GQPYYVSDGH PVNSFEFVKP LLNSLGYDLP NYYLPVPKAL
PLGKFFALLY TILYPWLDRW WLPHPLMLPA EIYKVGVSNY FSYLKAKEEL GYAPMVTPKE
GMAATISFWQ EKKRKSLDGP TIYVWLYCVV GMSILFCAAF LPDVGPVPFF KAISLFFFRS
IKVVRMVFLV AFLLHVGEAI YAWFLARKVD PANSGGWFWQ TLALGIFSLR FLLKRARN
//
