ID A0A1S3C1L7_CUCME Unreviewed; 768 AA.
AC A0A1S3C1L7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Calcium permeable stress-gated cation channel 1 isoform X1 {ECO:0000313|RefSeq:XP_008455922.1, ECO:0000313|RefSeq:XP_008455924.1};
GN Name=LOC103495991 {ECO:0000313|RefSeq:XP_008455922.1,
GN ECO:0000313|RefSeq:XP_008455924.1, ECO:0000313|RefSeq:XP_008455925.1};
GN Synonyms=103495991 {ECO:0000313|EnsemblPlants:MELO3C019303.2.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008455925.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|EnsemblPlants:MELO3C019303.2.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_008455922.1, ECO:0000313|RefSeq:XP_008455924.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR RefSeq; XP_008455922.1; XM_008457700.2.
DR RefSeq; XP_008455924.1; XM_008457702.2.
DR RefSeq; XP_008455925.1; XM_008457703.2.
DR EnsemblPlants; MELO3C019303.2.1; MELO3C019303.2.1; MELO3C019303.2.
DR GeneID; 103495991; -.
DR Gramene; MELO3C019303.2.1; MELO3C019303.2.1; MELO3C019303.2.
DR KEGG; cmo:103495991; -.
DR eggNOG; KOG1134; Eukaryota.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR Proteomes; UP000596662; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF5; OS01G0534900 PROTEIN; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..176
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 197..359
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 370..642
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 719..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 87641 MW; F6D0EDF1F3A12BB0 CRC64;
MASIGDIGVG AAINILSAFA FFVVFALLRI QPVNDRVYFP KWYIKGLRGS PLSSGAIVGR
IVNLDFRSYL KFLNWMVAAL RMPEPELIDH AGLDSAVYLR IYLLGLKIFV PIACLAFTIM
VPVNYTNGTL ERSSLNYSNI DKLSISNIPI GSRRFWTHLV MAYVFTFWTC YILRKEYEIV
ASMRLHFLAS ENRRPDQYTV IVRNVPPDPD ESVSELVEHF FLVNHPDHYL THQIVYDANK
LSKLVEEKKK MQNWLDFYQL KYSRNQSKRA TVKTGFLGLW GDQVDAINYY SSKIEILSKE
ISLEADKTVS DPKSIMPAAF VSFKSRWGAA VCAQTQQSRN PTIWLTEWAP EPRDVYWDNL
AIPFVSLAIR RLIAGVAFFF LTFFFMIPIA FVQSLANIES IEKTAPFLRP IIELKFIKSV
IQGFLPGIAL KIFLIFLPSI LMLMSKFEGF ISRSSLERRS ASKYYIFLFV NVFLGSIITG
TAFQQLNKFL HQSANDIPKT IGVSIPMKAT FFITFIMVDG WAGIAAEILR LRPLIIYHLR
NFFLVKTEKD REEAMDPGTL EFNTGEPRIQ LYFLLGLVYA VVTPLLLPFI VTFFGLAYIV
YRHQIINVYN QEYESAAAFW PDVHGRIIAA LVVSQLLLMG LLSTKEAAQS TPLLIALPIL
TIWFNRFCKG RYEPAFVQYP LQEAMMKDTL ERAREPNLNL KGFLQNAYVH PVFKHDEDDV
EIETDSEDRQ QEPALVPTKR QSRRNTPLQS KHSGPLSSSH SEVDGGAS
//
